YAO Jia-qi, XIAO Yong-qing, LIU Ying, et al. Anti-inflammatory Effect Comparison of Water and Ethanol Extracts of Sanhuang Xiexin Tang and Component Analysis of Its Active Extracts[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 31-35.
DOI:
YAO Jia-qi, XIAO Yong-qing, LIU Ying, et al. Anti-inflammatory Effect Comparison of Water and Ethanol Extracts of Sanhuang Xiexin Tang and Component Analysis of Its Active Extracts[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 31-35. DOI: 10.13422/j.cnki.syfjx.2015130031.
Anti-inflammatory Effect Comparison of Water and Ethanol Extracts of Sanhuang Xiexin Tang and Component Analysis of Its Active Extracts
Objective: To determine the active extracts and uncover the material basis of Sanhuang Xiexin Tang
comparing the anti-inflammatory effect of its water and ethanol extracts. Method: Use the xylene-induced auricular swelling of mouse as screening model: oral administration
and calculate the inhibition degree of swelling to determine the active extracts. Meanwhile
conduct the component analysis for active extracts. Result: Compared with model group
decrease of swelling in different groups is observed
the swelling of mouse is significantly lower of ethanol extracts than water extracts (P<0.01) and the inhibition degree is about 46%. The swelling of mouse in the medium dose and high dose of ethanol extracts are significantly lower than water extracts (P<0.05)
the inflammatory effect of ethanol extract is better than water extracts. The ratio of flavone
anthraquinone and alkaloid in ethanol extracts is 9: 2: 5. Conclusion: The inflammatory effect of ethanol extracts is obvious
which has something to do with the component ratio within the extracts. And ethanol extracts is determined as the active extracts of Sanhuang Xiexin Tang.
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