Objective: To study the effect and mechanism of anti-inflammation of Jiawei Huoxiang Zhengqi soft capsule (JWHX) on dextran sulphate sodium salt (DSS) induced colitis model in mice. Method: Sixty ICR male mice were randomly divided into normal group

model group

JWHX in high

middle and low dose (0.60

0.30

0.15 g·kg-1) groups. DSS 35 g·L-1 was used to induce colitis model in mice

at the same time mice was given drug by intragastric administration for 7 days. The disease activity index (DAI) was scored daily. Mice was killed on the day 7

the histopathological score of each mouse colon was evaluated

the content of myeloperoxidase (MPO) in colonic tissue was measured. The levels of interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α) were measured. Result: Compared with normal group

in the model group the DAI score and the pathological score increased significantly

and the content of MPO

IL-6

TNF-α increased significantly in the colon

and colon length decreased significantly in mice(P<0.01). Compared with the model group

high and middle dose JWHX could significantly decrease the DAI score and the pathological score

and significantly increased length of colon and reduce the content of MPO in the colon

IL-6

and TNF-α levels(P<0.05

P<0.01);Low-dose JWHX could significantly reduce the DAI score

increased length of colon

and significantly reduce the content of MPO in the colon(P<0.05). Conclusion: JWHX has certain therapeutic effect on DSS-induced colitis in mice

and its mechanism may be related to the inhibition of the IL-6

TNF-α of inflammatory factor.