Objective: To observe the anti-hyperglycemic effect of the decoction of Rubus crataegiflolius roots in diabetic rats induced by alloxan. Method: Diabetic rat models were copied by iv alloxan through tail vein

then rats were randomly divided into 4 groups;the model group (distilled water

13.5 mL·kg-1)

the positive control group (metformin hydrochloride

210 mg·kg-1)

the low and high dose groups (decoction of R. crataegifloliums roots

1.35

2.70 g·kg-1) of 10 rats each. Another 10 healthy rats were assigned to the normal group (distilled water

13.5 mL·kg-1). The corresponding medicines were intragastrically administrated to rats once daily for 13 days. Changes of fasting blood-glucose (FBG)

nitrogen oxide (NO)

malonaldehyde (MDA)

superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were detected. The organ coefficient was calculated. Result: Compared with the normal group

the levels of FBG

SOD and GSH-Px increased

the levels of NO and MDA decreased in the model group (P<0.05). Compared with model group

the levels of FBG and GSH-Px decreased in the low and high dose groups (P<0.05)

the NO level increased in the low dose group (P<0.05)

the MDA levels increased in the high dose group (P<0.05)

and the SOD level decreased in the high dose group (P<0.05). Moreover

the organ damage could be repaired by R. crataegifldiums roots decoction. Conclusion: R. crataegiflolius roots decoction could decrease blood glucose by improving the anti-oxidation function of the body and the functional recovery of the isle.