MIAO Jian-hong, BAI Jing, LI Jian-cheng, et al. Effects of Rutin on Renal Function and Pathological Changes in Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 122-125.
DOI:
MIAO Jian-hong, BAI Jing, LI Jian-cheng, et al. Effects of Rutin on Renal Function and Pathological Changes in Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 122-125. DOI: 10.13422/j.cnki.syfjx.2015130122.
Effects of Rutin on Renal Function and Pathological Changes in Diabetic Nephropathy Rats
Objective: To investigate the effects of rutin on renal function and pathological changes in diabetic nephropathy rats. Method: The model of diabetes nephropathy in rats was made by intraperitoneally injecting alloxan at 70 mg·kg-1 once weekly for 3 times continuously. The model rats were randomly divided into the model group
the high-
low-dose rutin groups (100
200 mg·kg-1) and the irbesartan group (20 mg·kg-1). The healthy rats were assigned to the normal group. The corresponding medicines were intragastrically administrated to rats once daily for 12 weeks. Levels of fasting blood glucose (FBG)
serum creatinine (SCr)
blood urea nitrogen (BUN) in serum
24-h urine protein and kidney index were tested. The renal pathological changes were examined by HE staining
Masson staining and electron microscopy. Result: Compared with the normal group
the levels of FBG
SCr
BUN
24-h urine protein and kidney index all increased (P<0.01)
kidney tissues such as glomerulus atrophy
renal capsule enlargement
renal interstitial area appearing much blue collagenous fiber
basilar membrane thicken diffusely
and fusion of foot process were injured remarkably in the model group. Compared with model group
rutin could decrease the levels of SCr
BUN
24-h urine protein and kidney index (P<0.05
P<0.01). Conclusion: Rutin could improve the kidney function and reduce the renal injury degree in diabetic rats.
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