Effect of Dendritic Cells and HBV-DNA to Chronic Hepatitis B Patients with Liangxue Zishen Yiqi Method

LU Yan-ping; ZHOU Da-qiao; XIONG Yi-qun; GAO Hui; HE Jin-song; CHEN Ying-jie; WEI Chun-shan; CHEN Liang; XU Wen-jun; LI Qun

doi:10.13422/j.cnki.syfjx.2015130160

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Effect of Dendritic Cells and HBV-DNA to Chronic Hepatitis B Patients with Liangxue Zishen Yiqi Method

更新时间：2024-01-04

- Effect of Dendritic Cells and HBV-DNA to Chronic Hepatitis B Patients with Liangxue Zishen Yiqi Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 13, Pages: 160-164(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015130160
  CLC： R259
- Published：2015
- 稿件说明：
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LU Yan-ping, ZHOU Da-qiao, XIONG Yi-qun, et al. Effect of Dendritic Cells and HBV-DNA to Chronic Hepatitis B Patients with Liangxue Zishen Yiqi Method[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 160-164.
DOI：

LU Yan-ping, ZHOU Da-qiao, XIONG Yi-qun, et al. Effect of Dendritic Cells and HBV-DNA to Chronic Hepatitis B Patients with Liangxue Zishen Yiqi Method[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 160-164. DOI： 10.13422/j.cnki.syfjx.2015130160.

摘要

目的: 探讨凉血滋肾益气法对慢性乙型肝炎患者乙型肝炎病毒-脱氧核糖核酸(HBV-DNA)

树突状细胞(dendritic cells

DCs)中表面分子表达水平及外周淋巴T细胞亚群等的影响

研究该中医治法对改善患者的免疫功能状态、抑制和清除病毒的作用

为防治病毒性乙型肝炎提供新思路。方法: 将158位患者随机分为治疗组80例

对照组78例

两组予常规保肝治疗

对照组加用中药颗粒模拟剂口服

治疗组加用凉血滋肾益气中药颗粒口服。结果: 治疗24周后

两组患者肝功

HBV-DNA

树突状细胞及外周淋巴T细胞亚群增殖均有明显改善

其中两组肝功指标改善情况无明显差异;治疗组24周后HBV-DNA明显降低

HBV-DNA水平下降>1 log10

>2 log10分别为51.25％

31.25％

与对照组33.33%

14.10%相比有显著差异性(P<0.05)

但阴转率无显著性差异。HBeAg阴转率较对照组有显著差异性

HBeAg血清学转换比例未能优于安慰剂对照组。治疗组DCs表面分子表达水平

DCs分泌IL-12水平均较对照组明显提高

差异均有显著性意义(P<0.01

P<0.05);对淋巴细胞亚群的增殖

主要是提高了CD4+

降低CD8+水平

与对照组比较差异有显著性差异(P<0.05)。结论: 凉血滋肾益气法对慢性乙型肝炎患者对DC、淋巴细胞亚群免疫调节细胞有积极影响

能明显降低HBV-DNA载量

提高HBeAg阴转率

可能与改善患者的免疫功能状态

激发调动患者的T淋巴细胞免疫状态有关。

Abstract

Objective: The aim of this study was to evaluate the effect of Liangxue Zishen Yiqi method on the level of hepatitis B virus-DNA(HBV-DNA)in dendritic cells (DCs)

and on the peripheral lymphoid T cell in patients with chronic hepatitis B

in order to study the role of Chinese medicine method in the immune function

inhibition and removal of the virus in patients

and provide the new ideas for prevention and treatment of hepatitis. Method: In this study

one hundred and fifty-eight cases of HBV patients were randomly divided into treatment group and control group. The conventional treatment was applied in the two groups

Liangxue Zishen Yiqi medicine was given in treatment group while Liangxue Zishen Yiqi placebo prescription was given in control group. All the traditional Chinese medicine were granular formulation. Result: After the treatment for 24 weeks

the liver function

HBV-DNA

dendritic cells and proliferation of peripheral lymphoid T cell subsets were obviously improved

with no significant difference in the improvement of liver function between two groups. The reduction of HBV-DNA after treatment in control group was significantly different with control group (P<0.05)

but with no significant difference in negative conversion ratio. The ratio of HBeAg negative conversion in treatment group was superior to the control group

however

the HBeAg sero conversion ratio was not. The levels of DCs molecules

and the secretion of DCs IL-12 levels were both superior to the control group (P<0.01

P<0.05);as to the proliferation of T lymphocyte subsets

it mainly improved the level of CD4+

and reduced the level of CD8+

with significant difference compared with control group (P<0.05). Conclusion: Liangxue Zishen Yiqi has positive effect on DC

lymphocyte subsets in patients with chronic hepatitis B. It can significantly restrain HBV-DNA

which may play a role in improving the immune function and arousing the T lymphocyte immune status of patients.

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