Clinical Efficacy of Tongmai Wendan Decoction on IMT and Blood Lipid of Patients with Carotid Artery Atherosclerosis

WU Xin-fang; LI Shu-bin; XIE Xiang-zhi; XU Guo-lei; WANG Ji-yuan

doi:10.13422/j.cnki.syfjx.2015130165

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Clinical Efficacy of Tongmai Wendan Decoction on IMT and Blood Lipid of Patients with Carotid Artery Atherosclerosis

更新时间：2024-01-04

- Clinical Efficacy of Tongmai Wendan Decoction on IMT and Blood Lipid of Patients with Carotid Artery Atherosclerosis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 13, Pages: 165-168(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015130165
  CLC： R285.6
- Published：2015
- 稿件说明：
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WU Xin-fang, LI Shu-bin, XIE Xiang-zhi, et al. Clinical Efficacy of Tongmai Wendan Decoction on IMT and Blood Lipid of Patients with Carotid Artery Atherosclerosis[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 165-168.
DOI：

WU Xin-fang, LI Shu-bin, XIE Xiang-zhi, et al. Clinical Efficacy of Tongmai Wendan Decoction on IMT and Blood Lipid of Patients with Carotid Artery Atherosclerosis[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 165-168. DOI： 10.13422/j.cnki.syfjx.2015130165.

摘要

目的: 评价通脉温胆汤对颈动脉硬化患者颈动脉内中膜厚度(intima-media thickness of carotid arteries

IMT)及血脂的影响。方法: 采用随机、对照的临床试验

将符合纳入标准的120名患者随机分入治疗组及对照组

所有的患者均医嘱改善生活方式

在此基础上

治疗组给予通脉温胆汤(配方颗粒)1袋

2次/d

早晚餐后服用

阿托伐他汀钙20 mg

1次/d

睡前服用;对照组给予阿托伐他汀20 mg

1次/d

睡前服用

疗程共3个月

观察治疗前后患者IMT

血脂及中医症状的改善情况。结果: 治疗后两组患者IMT及血脂均较治疗前有一定改善

IMT组间比较

差异无统计学意义

总胆固醇(TC)组间比较差异具有统计学意义(P<0.05)

低密度脂蛋白胆固醇 (LDL-C)组间比较差异具有统计学意义(P<0.05)

高密度脂蛋白胆固醇(HDL-C)组间比较差异具有统计学意义(P<0.05)

甘油三酯(triglyceride

TG)组间比较差异无统计学意义

两组患者眩晕改善情况差异具有统计学意义(P<0.05)

胸膈痞满改善情况差异具有统计学意义(P<0.05)

口黏腻改善情况差异具有统计学意义(P<0.05)。结论: 通脉温胆汤能够调节颈动脉硬化患者的胆固醇水平

改善患者的中医症状。

Abstract

Objective: To evaluate the clinical efficacy of Tongmai Wendan decoction in patients with carotid artery atherosclerosis. Method: One hundred and twenty patients according to inclusion criteria were randomly divided into treatment group and control group

patients from treatment group receive Tongmai Wendan decoction and atorvastatin

and patients from control group was given atorvastatin

and the treatment period was 3 months

intima-media thickness of carotid arteries(IMT)

blood lipid and symptoms before and after treatment were observed. Result: After treatment

IMT and blood lipid were improved in both groups

difference of IMT between the two groups was not statistically significant

difference of total cholesterol (TC)between the two groups was statistically significant(P<0.05)

difference of low density lipoprotein cholesterol(LDL-C) between the two groups was statistically significant(P<0.05)

difference of high density lipoprotein cholesterol(HDL-C) between the two groups was statistically significant(P<0.05)

difference of trigly-ceride(TG) between the two groups was not statistically significant

some clinical symptoms such as dizziness

full feeling of the chest and sticky and greasy in mouth were improved in treatment group

the difference was statistically significant(P<0.05). Conclusion: Tongmai Wendan decoction can regulate the level of blood lipid in patients with carotid artery atherosclerosis and improve the symptoms of patients.

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