Objective: The aim of this study was to probe into the application value of the combination of Chinese medicine cycle treatment and letrozole for patients with ovulation disorder infertility in Shenxu Xueyu type. Method: The ninty-two patients with ovulatory disorder infertility in Shenxu Xueyu type were divided into treatment group and control group by digital form randomly. There were 46 cases in each group. The patients in the control group were treated with letrozole drug therapy. The patients in the treatment group were treated with letrozole combined with Chinese medicine cycle treatment. The clinical treatment of the patients in two groups were compared and analyzed. Result: Compared with control group

in treatment group

the recovery rate was 50.00% (23/46) and the total efficacy was 91.30%(42/46) with significant increase;after treatment

the primary follicular diameter was (19.89±3.25) mm

the endometrial thickness was (9.72±1.86) mm

both increased significantly;the ovulation rate was 76.09%

pregnancy rate was 45.65% and live birth rate was 90.48%

all increased significantly;while the abortion rate was 9.52%

which decreased significantly;after treatment

the levels of estradiol(E2) was (240.26±58.72) pmol·L-1

follicle-stimulating hormone(FSH) was (16.23±4.25) U·L-1

which both increased significantly

while the level of testosterone(T) was (1.69±0.30) nmol·L-1

luteinizing hormine(LH) was (24.35±6.18) U·L-1

LH/FSH was (1.51±0.73)

which all decreased significantly;after treatment

the scores of TCM syndrome was (5.36±1.20) points

which reduced significantly;the ratio of TCM syndromes cure was 54.35% (25/46)

the total efficiency was 95.65% (44/46)

with both increased significantly. The differences were significant (P < 0.05). Conclusion: Chinese medicine cycle treatment combined with letrozole has a positive role in promoting the clinical effects and improving the clinical symptoms for patients with ovulation disorder infertility in Shenxu Xueyu type. It could serve as the ideal clinical treatment solution for patients with ovulation disorder infertility in Shenxu Xueyu type.