Objective: The aim of this article was to study the effect of Houpu Wenzhong decoction combined with domperidone on plasma gastrointestinal hormone and curative effect on functional dyspepsia. Method: One hundred and fifteen cases with functional dyspepsia were divided into observation group (58 cases) and control group (57 cases)

with control group given domperidone and observation group treated with domperidone and Houpu Wenzhong decoction. Efficacy

clinical symptoms scores

plasma gastrointestinal hormone level

and adverse drug reactions were compared between two groups. Result: Curative efficacy in observation group was significantly higher than that in control group (94.83% VS 80.70%);clinical symptom scores were all significantly lower than those in control group;in observation group

plasma motilin level was significantly higher than in control group [(279.31±60.47) VS (224.54±57.62) ng·L-1]

and the plasma somatostatin in observation group was significantly lower than in control group[(9.38±4.14)VS(12.53±3.79) ng·L-1];there was no obvious adverse drug reactions occurred in both two groups. Conclusion: Houpu Wenzhong decoction combined with domperidone can help to improve plasma motilin and somatostatin levels

relieve the clinical symptoms

and improve the clinical curative effect.