Effect of Shuangu Sanzi Capsules Combined Bushen Jiangu Capsules in Treating 60 Patients with Osteoportic

LI Yu; ZHANG Ning; SHANG Hong-tao; DONG Gui-xian

doi:10.13422/j.cnki.syfjx.2015130190

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Effect of Shuangu Sanzi Capsules Combined Bushen Jiangu Capsules in Treating 60 Patients with Osteoportic

更新时间：2024-01-04

- Effect of Shuangu Sanzi Capsules Combined Bushen Jiangu Capsules in Treating 60 Patients with Osteoportic
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 13, Pages: 190-193(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015130190
  CLC： R580
- Published：2015
- 稿件说明：
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LI Yu, ZHANG Ning, SHANG Hong-tao, et al. Effect of Shuangu Sanzi Capsules Combined Bushen Jiangu Capsules in Treating 60 Patients with Osteoportic[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 190-193.
DOI：

LI Yu, ZHANG Ning, SHANG Hong-tao, et al. Effect of Shuangu Sanzi Capsules Combined Bushen Jiangu Capsules in Treating 60 Patients with Osteoportic[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(13): 190-193. DOI： 10.13422/j.cnki.syfjx.2015130190.

摘要

目的: 探讨双骨三子胶囊联合补肾健骨胶囊治疗骨质疏松性骨折的临床疗效及对碱性磷酸酶(ALP)

骨钙素(BGP)和骨形态发生蛋白(BMP-2)的影响。方法: 将118例患者随机按住院前后顺序分为对照组58例和观察组60例。对照组采用碳酸钙D3咀嚼片

0.6 g·d-1

女性绝经患者加用阿仑膦酸钠片

10 mg·d-1。观察组在对照组治疗的基础上加服双骨三子胶囊

3粒/次

3次/d

和补肾健骨胶囊

4粒/次

3次/d

口服。两组疗程均为6个月。记录骨折愈合时间和骨痂生长情况;评价治疗前后腰背部疼痛情况

测量治疗前后股骨颈的骨密度

检测治疗前后血清ALP

BGP和BMP-2水平。结果: 经Ridit分析

观察组临床骨折愈合疗效优于对照组(P<0.05);治疗后观察组股骨颈的骨密度高于对照组(P<0.01)

腰背部疼痛评分均低于对照组(P<0.01);治疗后2月观察组骨痂生长情况评分高于对照组(P<0.01);观察组平均骨折愈合时间为(10.4±2.2)周

短于对照组的(13.2±2.6)周(P<0.01);治疗后观察组血清ALP水平低于对照组(P<0.01)

BGP和BMP-2水平高于对照组(P<0.01)。结论: 补肾健骨胶囊联合双骨三子胶囊治疗骨质疏松性骨折能促进骨折的愈合

缩短骨折愈合时间

增加骨密度

减轻疼痛

并能调节患者ALP

BGP

BMP-2水平。

Abstract

Objective: To discuss the clinical effect of Shuangu Sanzi capsules combined Bushen Jiangu capsules in treating osteoportic fracture

and to investigate its influence on alkaline phosphatase (ALP)

bone gla protein (BGP) and bone morphogenetic protein (BNP-2). Method: One hundred and eighteen patients were randomly divided into the control group (58 cases) and the observation group (60 cases). Patients in the control group received 0.6 g calcium carbonate D3 chewable tablet every day. For female patients during menopause

10 mg alendronate sodium tablets were added every day. Based on the treatment of the control group

patients in the observation group added 3 Shuangu Sanzi capsules and 4 Bushen Jiangu capsules thrice daily. All patients in both two groups received 6 months of treatment. Time of fracture healing and growth situation of bone callus was recorded. Before and after treatment

pain of waist and back was evaluated. The density of femur

tibia and levels of serous ALP

BGP and BMP-2 were detected. Result: The clinical effect of fracture healing in the observation group was superior to that in the control group (P<0.05). After treatment

density of the femur and tibia was higher (P<0.01)

scores of pain of the waist and back were lower in the observation group than those in the control group (P<0.01). After 2 months of treatment

score of growth situation of bone callus was higher (P<0.01)

the average time of fracture healing was lower in the observation group than those in the control group (P<0.01). Level of serous ALP was lower (P<0.01)

and levels of BGP and BMP-2 were higher in the observation group than those in the control group (P<0.01). Conclusion: Shuangu Sanzi capsules combined Bushen Jiangu capsules could promote the healing of fracture

reduce the time of fracture healing

increase bone mineral density

alleviate pain and regulate levels of ALP

BGP and BMP-2 in treating osteoportic fracture.

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