Total flavonoids are main active components of epimedium and icariin is one of the most important active substances of epimedium total flavonoids

which has wide pharmacological effects such as anti-inflammation

anti-tumor

anti-osteoporosis

and cardio cerebral vascular protection

et al. In this paper

documents of epimedium total flavonoids and icariin about cardiovascular protection were collected from domestic and international literature database such as CNKI

PubMed and SpringerLink et al. The research progress mainly related to anti-atherosis

anti-hypertension

effects on hemodynamics and hemorrheology

anti-myocardial ischemia

anti-heart failure

we also collected data for cytokine and intracellular signaling pathways mechanisms and analyzed them at different depth. This paper has important theoretical value and practical significance for the new drug of epimedium total flavonoids and icariin and provides reliable literature information for the further studies.