WU Liang-bing, PAN Yi, WANG Zhi-guo, et al. Effect of Tiaoganshen Qutanyu-formula on Histomorphology of Heart and Kidney Tissue on Early Stage of Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 82-86.
DOI:
WU Liang-bing, PAN Yi, WANG Zhi-guo, et al. Effect of Tiaoganshen Qutanyu-formula on Histomorphology of Heart and Kidney Tissue on Early Stage of Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 82-86. DOI: 10.13422/j.cnki.syfjx.2015140082.
Effect of Tiaoganshen Qutanyu-formula on Histomorphology of Heart and Kidney Tissue on Early Stage of Spontaneous Hypertensive Rats
Objective: To observe the effect of Tiaoganshen Qutanyu-formula (TQF) on histomorphology of kidney tissue injury index on the early stage of spontaneous hypertensive rats (SHR) administered before blood pressure peak. Method: A total of 30 12-week male SHR were randomly divided into 3 groups:the TQF group (4 g · kg-1)
the losartan group (30 mg · kg-1) and the model group. Another healthy 10 SD rats were taken as the normal group. The kidney and heart ultrastructure and protein expression of angiotensin Ⅱ were observed after 12 weeks of treatment. Result: Compared with the normal group
the kidney and heart ultrastructure had varying degrees of injuries
the protein expression of angiotensin Ⅱ increased in the model group (P<0.01). Compared with the model group
the kidney and heart ultrastructure had good improvement
the protein expression of angiotensin Ⅱ decreased in the TQF group (P<0.01). Conclusion: TQF taken before blood pressure peak could reduce the pathological injury of kidney and heart. The mechanism might be the synergistic effect of Yin-yang theory of preventing the aggregation of extra cellular matrix by reducing the expression of angiotensin Ⅱ.