Objective: To observe the effect of Fuzi Lizhong Tang on expression of colonic mucosal nuclear factor-κB(NF-κB)and serum tumor necrosis factor-α(TNF-α)

interleukin-1β(IL-1β) of the spleen and kidney Yang deficiency type ulcerative colitis(UC) rats. Method: Fourty-eight Wistar rats of SPF class were randomly divided into six groups: normal group

model group

low

middle and high dose groups of Fuzi Lizhong Tang and salicylazosulfapyridine(SASP) group(n=8 each

male and female in half).The normal group and model group were given physiological saline intragastrically;while Fuzi Lizhong Tang groups were administrated with Fuzi Lizhong Tang at dose of 3.51

7.03

14.06 g · kg-1 respectively and SASP group was given SASP of 0.46 g · kg-1. Investigation started from 3 days after modeling and continued for 15 successive days to observe the effect of Fuzi Lizhong Tang on expression of colonic mucosal NF-κB and serum TNF-α

IL-1β of UC rats. Result: Compared with normal group

model group significantly increased the level of mucosal inflammation and damage score. Compared with model group

Fuzi Lizhong Tang significantly improve the level of mucosal inflammation and damage score and reduce the expression of colonic mucosal NF-κB and serum TNF-α

IL-1β of the spleen and kidney Yang deficiency type UC rats(P<0.05). Conclusion: Fuzi Lizhong Tang can play a significant role in the anti-inflammatory and repair action in UC mice

its therapeutic mechanism may be related to inhibiting the activation of NF-κB and reducing the expression of TNF-α and IL-1β.