Objective: To observe clinical efficacy of Yiqi Huoxue Tongluo decoction combined with low-molecular-weight heparin in treating muscle recovery of patients with limb dysfunction and effect to Neuropeptide Y (NPY) and dynorphin (Dyn) after stroke. Method: One hundred ten patients were average divided into the control group and treatment group according to the order of admission. The control group was taken to abdominal subcutaneous injection of low-molecular-weight heparin

2 times/d. The treatment group was treated with Yiqi Huoxue Tongluo decoction combined with low-molecular-weight heparin. Both of the treatment lasted 8 weeks. Compared with activities of daily living (ADL)

balanced capacity

limb function and walking ability

Evaluating nerve function damage degree and clinical efficacy. Dyn and NPY level in blood plasma was detected. Result: The two groups could significantly increase the Basel index(BI)

Berg balance sheer(BBS)

Fuge-mehls(Fugl-Meyer)

and Functional walking scale(FAC) score

and the treatment group was better than the control group (P<0.05). The score of nerve function damage degree and muscle recovery in the treatment group was better than the control group (P<0.05). The two groups could significantly decrease the level of Dyn and NPY in plasma

and comparison between both groups was significant difference after treatment (P<0.05). Conclusion: Yiqi Huoxue Tongluo decoction combined with low-molecular-weight heparin can improve limb dysfunction after stroke

and its mechanism may be related with inhibiting levels of Dyn and NPY.