Tangmaikang Particles to Glucose Fluctuation of Patients with Type Two Diabetes Mellitus

HU Man-li; DENG Hong-yan; FU Jie; LIAO Li-ya

doi:10.13422/j.cnki.syfjx.2015140173

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Tangmaikang Particles to Glucose Fluctuation of Patients with Type Two Diabetes Mellitus

更新时间：2024-01-04

- Tangmaikang Particles to Glucose Fluctuation of Patients with Type Two Diabetes Mellitus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 14, Pages: 173-176(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015140173
  CLC： R285.6
- Published：2015
- 稿件说明：
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HU Man-li, DENG Hong-yan, FU Jie, et al. Tangmaikang Particles to Glucose Fluctuation of Patients with Type Two Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 173-176.
DOI：

HU Man-li, DENG Hong-yan, FU Jie, et al. Tangmaikang Particles to Glucose Fluctuation of Patients with Type Two Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 173-176. DOI： 10.13422/j.cnki.syfjx.2015140173.

摘要

目的: 观察糖脉康颗粒对2型糖尿病患者血糖、血脂水平及患者胰岛功能的影响。方法: 2012年1月至2014年6月本院内分泌科收治的230例2型糖尿病患者

采用随机数字表法分为对照组和观察组

对照组予口服二甲双胍片治疗

观察组在对照组治疗的基础上加服糖脉康颗粒

总治疗时间为8周

比较两组患者治疗前后的空腹血糖(FBG)

餐后2 h血糖(2 hPBG)及糖化血红蛋白(HbA1c);72 h动态血糖数据

血糖水平的标准差(SDBG)

平均血糖波动幅度(MAGE)

日渐血糖平均绝对差(MODD)及餐后血糖波动均值(MPPGE)

并计算胰岛抵抗指数(HOMA-IR)

胰岛β细胞分泌功能指数(HOMA-IS)和胰岛素敏感指数(ISI);血清甘油三酯(TG)

总胆固醇(TC)

高密度脂蛋白胆固醇(HDL-C)

低密度脂蛋白胆固醇(LDL-C)。结果: 治疗后两组患者SDBG

MAGE

MODD

MPPGE

HOMA-IR FBG

2 hPBG

HbA1c

LDL-C均较治疗前有所下降

观察组下降幅度更大(P<0.05)。HOMA-IS和ISI较治疗前有所升高

观察组升高更明显(P<0.05)。结论: 糖脉康颗粒有助于糖尿病患者血糖稳定

对保存患者胰岛功能改善血脂代谢有一定帮助

值得临床应用。

Abstract

Objective: The aim of this study was to siscuss the influence of Tangmaikang particles on glucose fluctuation and impact on oxidative stress

and the function of vascular endothelium in treating type-two diabetes mellitus (T2DM). Method: Two hundred and thirty patients with T2DM were randomly divided into control group and observation group by random number table.Patients in control group received repaglinide tablets.Based on the treatment of control group

patients in observation group were added Tangmaikang particles.Before and after treatment

continuous glucoses including standard deviation of blood glucose level (SDBG)

mean amplitude of glycemic excursions (MAGE)

mean of daily differences (MODD)

and mean postprandial glucose excursion (MPPGE)were monitored;and fasting blood-glucose (FBG)

fasting insulin(FINS)

two hours' postprandial blood glucose (2 hPBG) and glycosylated hemoglobin (HbA1c)were detected

and indexes of homeostasis model assessment of insulin resistance (HOMA-IR)

secretion function of pancreas islet B cell and insulin sensitivity(ISI) were calculated.The serum triglyceride (TG)

total cholesterol (TC)

high density lipoprotein (HDL-C)

and low density lipoprotein (LDL-C) were measured. Result: After treatment

indexes of SDBG

MAGE

MODD

MPPGE

HOMA-IR FBG

2 hPBG

HbA1c

TC and LDL-C in observation group were all lower than those in control group

but the indexes of HOMA-IS and ISl were higher than those in control group (P<0.05). Conclusion: Tangmaikang particles can reduce blood glucose of patients with T2DM

keep the stability of blood glucose

regulate the intraday glucose fluctuation

and improve blood lipid metabolism

which is worthy of clinical application.

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Related Institution

Key Laboratory of Modern Chinese Medicine Formulations of Jiangxi University of Chinese Medicine， Ministry of Education

School of Pharmacy， Jiangxi University of Chinese Medicine

National Key Laboratory of Creation of Modern Chinese Medicine with Classical Formulas

Dongfang Hospital， Beijing University of Chinese Medicine

Key Laboratory of Health Preservation and Rehabilitation， Ministry of Education， Beijing University of Chinese Medicine

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