Effects and Mechanism of Qianyang Yuyin Granules on Renal Microcirculation in Normal Dogs

SONG Heng-wen; SHI Le; FANG Zhu-yuan; ZHU Xuan-xuan; XU Li; ZHU Fang-fang; SHEN Yang; ZENG Tai-lin

doi:10.13422/j.cnki.syfjx.2015150129

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Effects and Mechanism of Qianyang Yuyin Granules on Renal Microcirculation in Normal Dogs

更新时间：2024-01-04

- Effects and Mechanism of Qianyang Yuyin Granules on Renal Microcirculation in Normal Dogs
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 15, Pages: 129-132(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015150129
  CLC： R285.5
- Published：2015
- 稿件说明：
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SONG Heng-wen, SHI Le, FANG Zhu-yuan, et al. Effects and Mechanism of Qianyang Yuyin Granules on Renal Microcirculation in Normal Dogs[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(15): 129-132.
DOI：

SONG Heng-wen, SHI Le, FANG Zhu-yuan, et al. Effects and Mechanism of Qianyang Yuyin Granules on Renal Microcirculation in Normal Dogs[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(15): 129-132. DOI： 10.13422/j.cnki.syfjx.2015150129.

摘要

目的: 观察潜阳育阴颗粒(Qianyang Yuyin granules

QYG)对正常麻醉犬肾脏微循环影响

并初步研究其作用机制。方法: 应用PowerLab系统记录十二指肠给予潜阳育阴颗粒前和给药后15~180 min不同时段比格犬肾脏微循环变化;犬分为正常组

QYG高、中、低剂量组(12.30

6.15

3.08 g ·kg-1)

卡托普利组(30 mg ·kg-1)和珍菊降压片组(0.14 g ·kg-1)

于给药前及给药后15

120

180 min通过股动脉取血

ELISA法检测血清中血管紧张素Ⅱ(AngⅡ)

内皮型一氧化氮合酶(eNOS)含量

化学法检测一氧化氮(NO)含量;给药3 h后取肾脏组织

ELISA法检测肾脏AngⅡ含量。结果: 潜阳育阴颗粒12.30 g ·kg-1剂量组给药后60~180 min正常麻醉犬的肾动脉微循环血流量明显上升(P<0.05)

给药180 min后肾脏组织AngⅡ含量明显下降(P<0.05)

给药90

120

180 min后

血清中AngⅡ明显下降(P<0.05)

eNOS和NO含量明显上升(P<0.05);潜阳育阴颗粒6.15 g ·kg-1剂量组给药后90~120 min内正常麻醉犬的肾动脉微循环血流量明显上升(P<0.05)

给药90

120 min后

血清中AngⅡ明显下降(P<0.05)

eNOS和NO含量明显上升(P<0.05);潜阳育阴颗粒低剂量组给药后180 min内正常麻醉犬各项指标变化不明显。结论: 潜阳育阴颗粒可改善肾脏微循环

其作用机制可能与降低循环及肾脏组织AngⅡ的含量

增加循环中eNOS及NO含量有关。

Abstract

Objective: To study the effects of Qianyang Yuyin granules(QYG) on renal microcirculation in normal dogs and to investigate the mechanism. Method: The renal microcirculation was determined by PowerLab system before giving QYG (3.08

6.15

12.30 g · kg-1)and after 15

120

180 min respectively. Result: Compared with the normal group

QYG(12.30 g · kg-1)could increase the renal microcirculation(P<0.05

60-180 min)

the contents of nitric oxide synthase (eNOS)(P<0.05) and nitric oxide(NO) in the serum(P<0.05

90-180 min) and reduce the contents of angiotensinⅡ(AngⅡ)in the serum(P<0.05

90-180 min)and kidney (P<0.05

180 min);QYG(6.15 g · kg-1) could increase the renal microcirculation(P<0.05

90-120 min)

the contents of eNOS and NO in the serum(P<0.05

90-120 min)and reduce the contents of Ang Ⅱ in the serum(P<0.05

90-120 min). The effects of QYG(3.08 g · kg-1) were not obvious. Conclusion: QYG could improve renal microcirculation

its mechanism may be associated with the decreasing circulation and kidney tissue AngⅡ content

increasing the circulation of eNOS and NO contents.

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