Clinical Observation of Tongmai Yangxin Pills and Compound Danshen Tablets in Treating 54 Cases with Chronic Stable Angina Qi-deficency and Blood-stasis Syndromes
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Clinical Observation of Tongmai Yangxin Pills and Compound Danshen Tablets in Treating 54 Cases with Chronic Stable Angina Qi-deficency and Blood-stasis Syndromes
Chinese Journal of Experimental Traditional Medical FormulaeVol. 21, Issue 15, Pages: 172-175(2015)
WU Li-hong, CHEN Qiao, ZHANG Bo. Clinical Observation of Tongmai Yangxin Pills and Compound Danshen Tablets in Treating 54 Cases with Chronic Stable Angina Qi-deficency and Blood-stasis Syndromes[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(15): 172-175.
DOI:
WU Li-hong, CHEN Qiao, ZHANG Bo. Clinical Observation of Tongmai Yangxin Pills and Compound Danshen Tablets in Treating 54 Cases with Chronic Stable Angina Qi-deficency and Blood-stasis Syndromes[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(15): 172-175. DOI: 10.13422/j.cnki.syfjx.2015150172.
Clinical Observation of Tongmai Yangxin Pills and Compound Danshen Tablets in Treating 54 Cases with Chronic Stable Angina Qi-deficency and Blood-stasis Syndromes
Objective: To discuss the clinical efficacy of Tongmai Yangxin pills and compound Danshen tablets in treating chronic stable angina(Qi-deficency and blood-stasis syndromes) and improving the quality of life. Method: Totally 108 patients were randomly divided into the control group (54 cases) and the observation group (54 cases). The control group took aspirin tablets (100 mg/time
qd)
Metoprolol tablets (100 mg/time
bid) and Simvastatin tablets (20 mg/time
qd). Based on the therapies of the control group
the observation group were additionally given Tongmai Yangxin pills (40 pills/time
bid) and compound Danshen tablets (4 pills/time
2 qd). When necessary
both groups can sublingually take Nitroglycerin tablets (0.5 or 1 tablet/time at the interval of 5 min). Both groups were treated for 12 weeks. During the study
efforts were made to record Angina frequency
score Qi-deficency and blood-stasis syndromes before and after the treatment
detect electrocardiogram before and after the treatment
record nitroglycerin stop and reduction and adopt seattle angina questionnaire (SAQ) to evaluate the quality of life. Result: According to Ridit analysis
the Electrocardiogram efficacy in the observation group was higher than that in the control group (P<0.05). angina efficacy in the observation group was better than that in the control group (P<0.05). The Qi-deficency and blood-stasis syndromes score in the observation group was less than that in the control group at the eighth and twelfth weeks after the treatment (P<0.01)
with a higher decline decrease degree than the control group (P<0.01). After the treatment
the nitroglycerin stop and reduction rate in the observation group was 90.74% and higher than 74.07% in the control group (P<0.05). After the treatment
the limited physical activity level
angina stabilization state
angina frequency
treatment satisfaction in the observation group were higher than that in the control group (P<0.05
P<0.01). Conclusion: On the basis of conventional western medicine therapies
Tongmai Yangxin pills and compound Danshen tablets can reduce the angina frequency of patients with chronic stable angina (Qi-deficency and blood-stasis syndromes) and the use of nitroglycerin
relieve Qi-deficency and blood-stasis syndromes and electrocardiogram and enhance the patient's quality of life.