Objective: To establish a method for determining ginsenoside Rg1

Re

Rb1

Rd and astragaloside Ⅳ in Yixinshu dispersible tablets. Method: By using HPLC-ELSD

Shim-pack ODS column was eluted with the mobile phase of acetonitrile-water at the flow rate of 1.0 mL · min-1. Result: According to the regression equation

ginsenoside Rg1

ginsenoside Re

ginsenoside Rb1

ginsenoside Rd and astragaloside Ⅳ showed a good linear relationship at 0.685-3.428 μg (r=0.999 5)

1.819-9.094 μg (r=0.999 0)

3.717-18.586 μg (r=1)

1.042-5.212 μg (r=0.999 5)

0.388-1.940 μg (r=0.999 8)

respectively. The average recoveries were 100.05% (RSD 1.6%) for ginsenoside Rg1

96.21% (RSD 1.1%) for ginsenoside Re

96.20% (RSD 1.1%) for ginsenoside Rb1

100.52% (RSD 2.5%) for ginsenoside Rd and 99.26% (RSD 1.6%) for astragaloside Ⅳ. Conclusion: This method is simple

accurate and highly reproducible and so can be used to simultaneously determine multiple components and control the quality of Yixinshu dispersible tablets.