MIAO Yan-yan, ZHANG Yong-ping, YANG Xiang-yu, et al. Effect of Dantian Jingshu Capsule on Hemorheology of CSA Model Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(16): 143-146.
DOI:
MIAO Yan-yan, ZHANG Yong-ping, YANG Xiang-yu, et al. Effect of Dantian Jingshu Capsule on Hemorheology of CSA Model Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(16): 143-146. DOI: 10.13422/j.cnki.syfjx.2015160143.
Effect of Dantian Jingshu Capsule on Hemorheology of CSA Model Rabbits
Objective: To investigate the effect of Dantian Jingshu capsule onhemorheology of vertebral artery type cervical spondylosis (CSA) model rabbits. Method: Seventy rabbits were randomly divided into 7 groups:normal group
model group
Dantian Jingshu capsule group(0.36
0.72
1.44 g · kg-1)
positive control group(Jing Fukang granules 1.0 g · kg-1 and flunarizine 0.001 g · kg-1). Rabbits were injected with 775 injection(tissue sclerosing agent) in the left side of cervical vertebrae to make animal model of CSA. To observe the effects of Dantian Jingshu capsule on hemorheology[whole blood viscosity
plasma viscosity
whole blood viscosity reduction
hematocrit(HCT)
erythroeyte aggregation index(EAI)
red cell rigidity index(ERI)
red cell deformation index (EDI)and fibrinogen] of the rabbits by intragastric administration after two weeks. Result: Compared with normal group
the hemorheology index of model group (blood viscosity
plasma viscosity
HCT
whole blood viscosity reduction
EAI) were obviously decrease. So there was significant differences between normal group and model group(P <0.01). Compared with model group
blood viscosity and aggregation of red-cells were obviously decrease and erythrocyte deformability was increased in Dantian Jingshu capsule group(P <0.01). Conclusion: Dantian Jingshu capsule could reduce the CSA model rabbits erythrocyte aggregation and reinforce the ability of erythocyte deformability so that improve its blood viscosity. Dantian Jingshu capsule can improve the CSA model rabbits' symptom of cerebral ischaemia.
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