Objective: To study the effect of extracts from Clematidis Chinensis Radix et Rhizoma in treating diabetic nephropathy in rats. Method: Totally 50 SD rats were randomly divided into the normal group

the model group

the Captopril group (10 mg · kg-1)

Clematidis Chinensis Radix et Rhizoma extracts high and low dose groups (500

250 mg · kg-1)

with 10 rats in each group. Except for the normal group

the rest groups were intraperitoneally injected with streptozotocin (STZ) to prepare the diabetic rat model and then orally given corresponding drugs

qd

for 12 weeks. The effect of extracts from Clematidis Chinensis Radix et Rhizoma on urea nitrogen(BUN)

serum creationine(SCr)

creatimine clearance rate(CCr)

urinary albumin

urinar protein excretion rate(UAER)

kidney hypertrophy index

fasting blood glucose

triglyceride(TG)

total cholesterol(TC)

low density lipoprotein cholesterol(LDL-C)

high density lipoprotein cholesterol(HDL-C)

interleukin-6(IL-6)

malondialdehyde(MDA)

superoxide dismutase(SOD)

glutathion peroxidase(GSH-Px) and Renal tissue pathomorphological changes. Result: Compared with the model group

the model group showed notably higher serum BUN

SCr

CCr

IL-6

urinary albumin

UAER

kidney hypertrophy index and fasting blood glucose

TG

TC

LDL-c and MDA and lower HDL-C

SOD and GSH-Px

with notable statistical difference (P <0.05

P <0.01). In pathological tissues

renal glomerular basement membranes and renal tubule were thickened and swollen. Compared with the model group

extracts from Clematidis Chinensis Radix et Rhizoma showed remarkably lower BUN

SCr

CCr

IL-6

urinary albumin

UAER

kidney hypertrophy index and FBG (P <0.05)

TG

TC and LDL-C (P <0.05)

renal MDA content (P <0.05) and renal glomerular basement membrane and renal tubule thickening and swelling and higher HDL-C (P <0.05) and SOD and GSH-Px (P <0.05). Conclusion: Extracts from Clematidis Chinensis Radix et Rhizoma has a significant inhibitory effect on renal injury induced by diabetic nephropathy.