Objective: To study the hypoglycemic effect of wild Ligularia schmidtii(LS)picked in Changbai Mountain at different times by detecting the fasting blood glucose

insulin

liver glycogen

muscle glycogen and glucose tolerance in mice. Method: Totally 100 Kunming mice were randomly divided into the normal group

the model group

the metformin hydrochloride group (125 mg · kg-1) and LSMM groups (1.25 g · kg-1) picked at different times (including plants picked on May 15

May 30

June 15

June 30

July 15

July 30

August 15)

with 10 mice in each group. Except for the normal group

all of the rest groups were intraperitoneally injected with 200 mg · kg-1 sterilized saline water and 1% alloxan solution for 72 h to establish the model. After the modeling

they were orally administered with drugs (0.01 mL · g-1). The fasting blood glucose value

serum insulin content

liver glycogen content

muscle glycogen content and glucose tolerance of mice were measured with Appropriate kits. Result: Compared with the normal group

the model group showed significant increase in the fasting blood glucose and decreases in insulin

liver glycogen and muscle glycogen content in mice at different time points

all with significant statistical differences (P <0.05). Compared with the normal group

LS picked at different times could decrease the fasting blood glucose and increase liver glycogen and muscle glycogen content in diabetic mice to varying degrees and alleviate the damaging effect of alloxan on pancreatic islet β cells in mice to some extent. Besides

compared with the normal group

it could also enhance glucose tolerance in normal mice to varying degrees

with the most significant hypoglycemic effect in LS picked in June (P <0.05) as evidenced by its blood glucose decrease by 35.66% in LS picked on June 30. Conclusion: LS picked at different times have the hypoglycemic effect on both diabetic mice and normal mice.