Sodium Ozagrel Combined with Dengzhan Xixin Preparations in Treatment of Cerebral Infarction

ZENG Chao; ZHENG Fang; TANG Jian; TAN Cai-hong; WANG Hua-jun

doi:10.13422/j.cnki.syfjx.2015160201

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Sodium Ozagrel Combined with Dengzhan Xixin Preparations in Treatment of Cerebral Infarction

更新时间：2024-01-04

- Sodium Ozagrel Combined with Dengzhan Xixin Preparations in Treatment of Cerebral Infarction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 16, Pages: 201-207(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015160201
  CLC： R743.3
- Published：2015
- 稿件说明：
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ZENG Chao, ZHENG Fang, TANG Jian, et al. Sodium Ozagrel Combined with Dengzhan Xixin Preparations in Treatment of Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(16): 201-207.
DOI：

ZENG Chao, ZHENG Fang, TANG Jian, et al. Sodium Ozagrel Combined with Dengzhan Xixin Preparations in Treatment of Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(16): 201-207. DOI： 10.13422/j.cnki.syfjx.2015160201.

摘要

目的: 系统评价奥扎格雷钠联合灯盏细辛制剂治疗脑梗死的疗效和安全性。方法: 计算机检索PubMed

EMbase

Cochrane Library

西文生物医学期刊文献数据库

中国期刊全文数据库

维普数据库

万方数据库

收集奥扎格雷钠联合灯盏细辛制剂治疗脑梗死的临床随机对照实验(RCT)。对纳入的研究进行方法学质量评价

并采用Rev Man 5.3.4统计软件进行Meta分析。结果: 共纳入22项RCT

合计2 198例患者。Meta分析结果显示

奥扎格雷钠联合灯盏细辛制剂能够显著提高患者的总有效率[OR＝3.76

95％CI(2.84

4.97)

P< 0.000 01]、显效率[OR＝2.07

95％CI(1.71

2.49)

P< 0.000 01] 及改善神经功能缺损评分[MD＝-5.08

95％CI(-5.73

-3.53)

P< 0.000 01]

差异均有统计学意义。结论: 奥扎格雷钠联合灯盏细心制剂治疗脑梗死疗效显著

未见明显不良反应

但受纳入文献质量限制

其疗效有待于高质量的随机对照实验进一步证实。

Abstract

Objective: To systematically evaluate the efficacy and safety of sodium ozagrel combined with Dengzhan Xixin preparations in treating cerebral infarction (CI). Method: Randomized controlled trails (RCT) about sodium ozagrel combined with Dengzhan Xixin preparations in the treatment of CI were collected by retrieving from PubMed

EMbase

Cochrane Library

FMJS

CNKI

VIP and Wanfang database. The methodological quality of the included studies was evaluated

and a Meta-analysis was made for them by Rev Man 5.3.4 statistical software. Result: A total of 22 RCT were included

involving 2 198 patients. The results of Meta-analysis showed that sodium ozagrel combined with Dengzhan Xixin preparations could significantly improve the total effective rate [OR＝3.76

95% CI (2.84

4.97)

P< 0.000 01]

obvious effective rate [OR＝2.07

95% CI (1.71

2.49)

P< 0.000 01] and neurological deficit scores [MD＝-5.08

95% CI (-5.73

-3.53)

P< 0.000 01]

with statistical significance in their differences. Conclusion: Sodium ozagrel combined with Dengzhan Xixin preparations is efficient in the treatment of CI

with no significant adverse reaction. However

restricted by the low methodological quality of the trials enrolled in the study

its efficacy shall be further confirmed by a high-quality RCT.

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Related Institution

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