Transdermal Effect of Euodiae Fructus Oil-in-water Microemulsion Cataplasm

ZHANG Guang-chang; GUO Yin-rui; WU Zhe-li; WANG Jian

doi:10.13422/j.cnki.syfjx.2015170001

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Transdermal Effect of Euodiae Fructus Oil-in-water Microemulsion Cataplasm

更新时间：2024-01-04

- Transdermal Effect of Euodiae Fructus Oil-in-water Microemulsion Cataplasm
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 17, Pages: 1-4(2015)
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- DOI：10.13422/j.cnki.syfjx.2015170001
  CLC： R283.6
- Published：2015
- 稿件说明：
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ZHANG Guang-chang, GUO Yin-rui, WU Zhe-li, et al. Transdermal Effect of Euodiae Fructus Oil-in-water Microemulsion Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 1-4.
DOI：

ZHANG Guang-chang, GUO Yin-rui, WU Zhe-li, et al. Transdermal Effect of Euodiae Fructus Oil-in-water Microemulsion Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 1-4. DOI： 10.13422/j.cnki.syfjx.2015170001.

摘要

目的: 考察水包油微乳巴布剂与常规巴布剂对吴茱萸脂溶性成分体外释放性能的差异

为巴布剂制备工艺的改进提供参考。方法: 按吴茱萸提取物-肉豆蔻酸异丙酯-丙二醇-聚山梨酯80-氢化蓖麻油-水(0.3:0.6:3.6:3.6:3.6:18)制备水包油微乳

将微乳添加至巴布剂基质制成水包油微乳巴布剂。采用体外扩散池法测定巴布剂中吴茱萸碱和吴茱萸次碱的体外透皮累积渗透量。结果: 吴茱萸水包油微乳巴布剂中的吴茱萸碱、吴茱萸次碱24 h单位面积累积渗透量分别为常规巴布剂的1.86

1.40倍。结论: 采用微乳工艺制备的巴布剂中吴茱萸脂溶性成分的释放性能明显优于传统方法制备的巴布剂

适合中药水难溶性成分巴布剂的制备。

Abstract

Objective: To study in vitro release difference of oil-in-water microemulsion cataplasm and conventional cataplasm to liposoluble components from Euodiae Fructus. Method: According to ratio of Euodiae Fructus extract-isopropyl myristate-propylene glycol-ploysorbae 80-hydrogenated castor oil-water (0.3: 0.6: 3.6: 3.6: 3.6: 18) for preparing oil-in-water microemulsion

then microemulsion was added to matrix for preparing microemulsion cataplasm.In vitro diffusion method was adopted to determine in vitro cumulative permeation quantity of evodiamine and rutaecarpine in cataplasm. Result: Cumulative permeation quantity per unit area at 24 h of evodiamine and rutaecarpine in Euodiae Fructus oil-in-water microemulsion cataplasm were 1.86

1.40 times to conventional cataplasm

respectively. Conclusion: Release performance of liposoluble components from Euodiae Fructus in microemulsion cataplasm is better than those in conventional cataplasm

which is suitable for preparation of water-insoluble ingredients cataplasm.

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