Effect of Tongfengan Liquid on Hyperuricemia Mice

YI Yan-dong; LIN Shi-he; XU Hong-feng; MA Wei

doi:10.13422/j.cnki.syfjx.2015170134

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Effect of Tongfengan Liquid on Hyperuricemia Mice

更新时间：2024-01-04

- Effect of Tongfengan Liquid on Hyperuricemia Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 17, Pages: 134-137(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015170134
  CLC： R285.5
- Published：2015
- 稿件说明：
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YI Yan-dong, LIN Shi-he, XU Hong-feng, et al. Effect of Tongfengan Liquid on Hyperuricemia Mice[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 134-137.
DOI：

YI Yan-dong, LIN Shi-he, XU Hong-feng, et al. Effect of Tongfengan Liquid on Hyperuricemia Mice[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 134-137. DOI： 10.13422/j.cnki.syfjx.2015170134.

摘要

目的: 观察痛风安液对高尿酸血症小鼠的影响。方法: SPF级昆明种雄性小鼠115只

随机分为正常组(等容蒸馏水)

模型组(等容蒸馏水)

别嘌呤醇(40 mg·kg-1)组

秋水仙碱(0.25 mg·kg-1)组

痛风安液低、中、高剂量(8.45

16.9

33.8 g·kg-1)组

每组15只

连续ig 28 d

末次给药1 h后检测血清尿酸水平

肌酐(Cr)

尿素氮(BUN)

白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)含量以及肝脏黄嘌呤氧化酶(XOD)活性。结果: 与正常组比较

模型组小鼠血尿酸水平

XOD活性及Cr

BUN

IL-6

TNF-α水平明显升高(P<0.01);与模型组比较

痛风安各剂量组可明显降低小鼠血尿酸水平

XOD活性及Cr

BUN

IL-6

TNF-α水平(P<0.05

P<0.01)。结论: 痛风安液对高尿酸模型小鼠有治疗和保护作用。

Abstract

Objective: To observe the effect of Tongfengan liquid (TFAL) on hyperuricemia mice. Method: Totally 115 SPF-grade KM mice were divided into the blank group (the same volume of distilled water)

the model group (the same volume of distilled water)

the allopurinol group (40 mg·kg-1)

the colchicine tablets group (0.25 mg·kg-1) and TFAL low

medium and high doses groups (8.45

16.9

33.8 g·kg-1)

with 15 mice in each group. They were orally administered with drugs for 28 days. One hour after the last administration

the serum uric acid level

creatinine (Cr)

urea nitrogen (BUN)

interleukin-6(IL-6)

tumor necrosis factor-α(TNF-α) contents and xanthine oxidase (XOD) activity levels were detected. Result: Compared with the normal group

the model group showed significant increases in hyperuricemia level

XOD activity and contents of Cr

BUN

IL-6 and TNF-α (P<0.01). Compared with the model group

the level of uric acid

XOD activity and contents of Cr

BUN

IL-6 and TNF-α in each TFAL group were significantly lower (P<0.01). Conclusion: TFAL has therapeutic and protective effects on hperuncemia mice.

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