Objective: To explore the effect of salvianic acid A and tanshinone ⅡA on the mesenteric microcirculation disturbance. Method: Totally 40 SD rats were randomly divided into five groups:the normal group

the model group

the positive control Phentolamine group (10 mg·kg-1)

the salvianic acid A group (30 mg·kg-1) and the tanshinone ⅡA group (30 mg·kg-1). Noradrenaline (NA) was given on mesentery to induce the local microcirculation disturbance. Drugs (salvianic acid A

tanshinone ⅡA

phentolamine or normal saline) were injected through sublingual veins. After 10 min

the mesenteric region that is 20 cm from the ileocecal region was dropped with 100 μL of NA solution (0.05 g·L-1). At 1

3

5

10

20

30 min after the dropping with NA

the diameter of arterioles

blood flow pattern

capillary opening rate and recovery time of blood flow were observed by microscopy. Result: Compared with the normal group

the model group showed NA can significantly shrink mesenteric arterioles

increase blood flow pattern and recovery time of blood flow and reduce capillary opening rate

with statistical significance (P<0.01).Compared with the model group

salvianic acid A and tanshinone ⅡA can reduce NA-induced contraction of mesenteric arterioles in a certain extent

improve blood flow pattern

increase the opening rate of capillary network and shorten the recovery time of microcirculation disturbance. Conclusion: salvianic acid A and tanshinone ⅡA have the effect in improving NA-induced mesenteric microcirculation disturbance in rats.