LI Mei, HU Lin-lin, ZHANG Yong-hua. Jiawei Suanzaoren Decoction Combined With Eszopiclone in Treating Anxiety Insomnia and Its Effect on 5-hydroxytryptamine and Dopamine[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 161-164.
DOI:
LI Mei, HU Lin-lin, ZHANG Yong-hua. Jiawei Suanzaoren Decoction Combined With Eszopiclone in Treating Anxiety Insomnia and Its Effect on 5-hydroxytryptamine and Dopamine[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 161-164. DOI: 10.13422/j.cnki.syfjx.2015170161.
Jiawei Suanzaoren Decoction Combined With Eszopiclone in Treating Anxiety Insomnia and Its Effect on 5-hydroxytryptamine and Dopamine
Objective: To investigate the efficacy of Jiawei Suanzaoren decoction combined with eszopiclone in treating anxiety insomnia and its effects on level on 5-hydroxytryptamine (5-HT) and dopamine (DA). Method: Totally one hundred and twenty cases of anxiety insomnia were randomly divided into two groups by the random number table
the control group and the observation group
with 60 cases in each group. The control group was treated with eszopiclone
while the observation group was treated with Jiawei Suanzaoren decoction combined with eszopiclone. The curative efficacy of anxiety insomnia
scores of manifest anxiety scale
serum 5-HT
DA and adverse reactions were observed and compared. Result: The observation group showed a total therapeutic efficiency ratio of 95.0%
which was significantly higher than that of 81.7% in the control group (P<0.05). In comparison with the control group
score of SAS
HAMA
5-HT
DA substantially increased
with statistical differences (all P<0.05). As for the adverse reactions
incidence of bitter taste in mouth and sleepiness in the observation group was statistically lower than that in the control group (all P<0.05)
with no statistical difference in incidences of nausea
constipation and dizziness between the two groups. Conclusion: Jiawei Suanzaoren decoction combined with eszopiclone in treating anxiety insomnia has a reliable efficacy
which can significantly increase the curative efficacy
alleviate anxiety emotion and regulate level of neurotransmitter
with lower incidence of adverse reactions. It is worth further studies in clinic.