Combined Administration of Traditional Chinese Medicines Through Different Approaches in Treating 55 Cases of Child Bronchial Asthma in Episodes of Intermingled Cold and Heat Symptoms

HUANG Yue; LIAO Bo-nian; WANG Jian-jun; LIU Chong-hai

doi:10.13422/j.cnki.syfjx.2015170177

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Combined Administration of Traditional Chinese Medicines Through Different Approaches in Treating 55 Cases of Child Bronchial Asthma in Episodes of Intermingled Cold and Heat Symptoms

更新时间：2024-01-04

- Combined Administration of Traditional Chinese Medicines Through Different Approaches in Treating 55 Cases of Child Bronchial Asthma in Episodes of Intermingled Cold and Heat Symptoms
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 17, Pages: 177-180(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015170177
  CLC： R272
- Published：2015
- 稿件说明：
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HUANG Yue, LIAO Bo-nian, WANG Jian-jun, et al. Combined Administration of Traditional Chinese Medicines Through Different Approaches in Treating 55 Cases of Child Bronchial Asthma in Episodes of Intermingled Cold and Heat Symptoms[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 177-180.
DOI：

HUANG Yue, LIAO Bo-nian, WANG Jian-jun, et al. Combined Administration of Traditional Chinese Medicines Through Different Approaches in Treating 55 Cases of Child Bronchial Asthma in Episodes of Intermingled Cold and Heat Symptoms[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 177-180. DOI： 10.13422/j.cnki.syfjx.2015170177.

摘要

目的: 观察宣肺平喘汤内服和哮喘I方穴位敷贴加离子导入的多途径给药治疗儿童支气管哮喘(寒热错杂证)发作期的临床疗效及对患者白细胞介素-4(IL-4)

γ-干扰素(IFN-γ)

免疫球蛋白E(IgE)的影响。方法: 采用随机按数字表法将110例患者分为对照组和观察组各55例。对照组采用宣肺平喘汤内服治疗

观察组在对照组治疗的基础上加用哮喘I方穴位敷贴加离子导入。两组疗程均为2周。记录两组患儿咳嗽、喘息和肺部哮鸣音消失时间;检测治疗前后肺功能

包括最大呼气流量(PEF)和第1秒钟用力呼气容积与用力肺活量比值(FEV1/FVC);采用哮喘控制问卷(ACQ)评价哮喘控制情况;检测治疗前后IL-4

IFN-γ和IgE水平。结果: 治疗后观察组临床显效率为92.73%

对照组为78.18%

观察组优于对照组(P<0.05);观察组在咳嗽、喘息消失、肺部哮鸣音消失时间均明显短于对照组(P<0.01);治疗后观察组PEF和FEV1/FVC均高于对照组(P<0.01);治疗后观察组IL-4和IgE水平低于对照组

IFN-γ水平高于对照组(P<0.01);经卡方检验

观察组哮喘控制情况优于对照组(P<0.05)。结论: 宣肺平喘汤内服和哮喘I方穴位敷贴加离子导入的多途径给药治疗儿童支气管哮喘(寒热错杂证)发作期的临床疗效优于单一中药内服

其作用机制可能是通过调节免疫系统紊乱

减轻炎症反应来实现的。

Abstract

Objective: To observe the clinical efficacy of Xuanfei Pingchuan decoction for oral administration combined with asthma I formula for acupoint sticking and iontophoresiss in treating child asthma (intermingled cold and heat symptoms) and their effect on interleukin-4 (IL-4)

γ-interferon (IFN-γ) and immunoglobulin E (IgE). Method: Totally 110 patients with bronchial asthma (intermingled cold and heat symptoms) were divided into the control group (55 cases) and the observation group (55 cases) by random number table. The control group orally took Xuanfei Pingchuan decoction. The observation group received acupoint sticking and iontophoresiss of Xuanfei Pingchuan decoction. The course of treatment was 2 weeks for both groups. The time of cough

wheeze and pulmonary wheezing extinction time were recorded. Before and after the treatment

lung function

peak expiratory flow (PEF)

specific value of the first second forced expiratory volume and forced vital capacity (FEV1/FVC) were detected. The control of asthma was evaluated by asthma control questionnaire (ACQ). Serum IL-4

IFN-γ and IgE were detected before and after the treatment. Result: The obvious effective rate was 92.73% in the observation group

which was superior to 78.18% in the control group (P<0.05). The extinction times of coughing

wheezing and lung wheezing sound in the observation group were obviously shorter than that in the control group (P<0.01). After the treatment

PEF and FEV1/FVC in the observation group were higher than that in the control group (P<0.01). After the treatment

serum IL-4 and IgE in the observation group were lower than that in the control group

but with higher IFN-γ than the control group (P<0.01). According to the chi-square test

the asthma controlling effect in the observation group was better than that in the control group (P<0.05). Conclusion: The curative effect of Xuanfei Pingchuan decoction for oral administration combined with asthma I formula for acupoint sticking and iontophoresiss in treating child asthma (intermingled cold and heat symptoms) is superior to that of the simple administration of traditional Chinese medicine. Its mechanism may be related to the regulation in immune system disorders and the reduction in inflammation reactions.

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