Effect of Xiaoshuan Changrong Capsule on Hemorheology and Coagulation Function in Patients With Qi-deficiency and Blood-stasis Type Cerebral Ischemic Stroke
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Effect of Xiaoshuan Changrong Capsule on Hemorheology and Coagulation Function in Patients With Qi-deficiency and Blood-stasis Type Cerebral Ischemic Stroke
Chinese Journal of Experimental Traditional Medical FormulaeVol. 21, Issue 17, Pages: 190-194(2015)
WANG Zhu-min, WANG Feng, SUN Xue-ping, et al. Effect of Xiaoshuan Changrong Capsule on Hemorheology and Coagulation Function in Patients With Qi-deficiency and Blood-stasis Type Cerebral Ischemic Stroke[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 190-194.
DOI:
WANG Zhu-min, WANG Feng, SUN Xue-ping, et al. Effect of Xiaoshuan Changrong Capsule on Hemorheology and Coagulation Function in Patients With Qi-deficiency and Blood-stasis Type Cerebral Ischemic Stroke[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 190-194. DOI: 10.13422/j.cnki.syfjx.2015170190.
Effect of Xiaoshuan Changrong Capsule on Hemorheology and Coagulation Function in Patients With Qi-deficiency and Blood-stasis Type Cerebral Ischemic Stroke
Objective: To observe the effect of Xiaoshuan Changrong capsule on hemorheology and coagulation function in patients with Qi-deficiency and blood-stasis type cerebral ischemic stroke. Method: Totally eighty patients with Qi-deficiency and blood-stasis type cerebral ischemic stroke were randomly divided into the observation group and the control group
with 40 cases in each group. The control group was given the conventional therapy;while the observation group was given Xiaoshuan Changrong capsule
0.4 g once
three times daily
in addition to the therapy of the control group. Both groups were treated for 30 days. Before and after the treatment
nerve function defect scale (MESSS)
modified barther index(MBI) were assessed
and hemorheological indexes (whole blood viscosity high shear
low shear
plasma viscosity
hematocrit(HCT)
fibrinogen(Fib)
erythrocyte sedimentation rate(ESR)
coagulation indexes [prothrombin time(PT)
activated partial thromboplastin time(APTT)
platelet oggregation rate(PAR) and D-dimmer] and therapeutic indexes (infarct volume
MESSS score and MBI) were monitored. Result: Before the treatment
hemorheological indexes [whole blood viscosity high shear
low shear
plasma viscosity
HCT
Fib and ESR)
coagulation indexes [PT
APTT
PAR and D-dimmer) and therapeutic indexes (infarct volume
MESSS score and MBI) showed no significant differences between both groups
with the comparability. After the 30-day treatment
total efficiency in the observation group was higher than that in the control group (P<0.05)
and hemorheology indexes
coagulation indexes and therapeutic effect indexes in the observation group were superior to that in the control group (P<0.05
P<0.01)
with no obvious adverse reaction in the observation group. Conclusion: Xiaoshuan Changrong capsule is safe and effective in treating cerebral ischemic stroke. Its action mechanism may be correlated with the improvement in blood rheology and anticoagulant function. [Key words] Xiaoshuan Changrong capsules;cerebral ischemic stroke;Qi-deficiency and blood-stasis;hemorheology;blood coagulation
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Related Institution
Wangjing Hospital of China Academy of Chinese Medical Sciences
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