Objective: To conduct a Meta-analysis on clinical study literatures for the effect of spleen invigorating and Qi replenishing therapy in treating dysfunctional uterine bleeding

in order to evaluate its efficacy and provide basis and clinical reference for traditional Chinese medicine(TCM) therapies in treating dysfunctional uterine bleeding. Method: PubMed

CBM

CNKI database were searched through computer to collect spleen invigorating and Qi replenishing therapy for dysfunctional uterine bleeding in randomized controlled trials. Two researchers independently selected literatures

extracted data and conducted a Meta-analysis according to the study method recommended by RevMan5.3 software. Result: Totally 11 study literatures involving 1 077 cases were selected

including 569 cases in the test group and 508 cases in the western medicine control group. According to the result of the Meta-analysis

the groups were subdivided by outcome indexes. The comparison between TCM and western medicine groups in the TCM syndrome efficacy showed[OR=3.64

95%CI(2.02

6.59)

Z=4.28

P<0.000 01]

the comparison between both groups in the overall menstruation efficacy showed[OR=3.78

95%CI (2.49

5.74)

Z=6.24

P<0.000 01]

and the comparison between both groups in the recent hemostatic efficacy showed[OR=1.47

95%CI (0.55

3.93)

Z=0.77

P=0.44]. Conclusion: The spleen invigorating and Qi replenishing therapy showed a certain clinical efficacy in treating dysfunctional uterine bleeding and so can be used as a clinical therapeutic option. However

due to the low quality of the included literatures

there is still certain publication bias. The above results shall be further proved on the basis of the evidence-based medicine in high-quality clinical studies in the future.