DANG Yan-qi, DUAN Ju, NI Rong-zhen, et al. Biological Activity and Structure-Activity Relationship of Prenylated Flavonoids[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 213-218.
DOI:
DANG Yan-qi, DUAN Ju, NI Rong-zhen, et al. Biological Activity and Structure-Activity Relationship of Prenylated Flavonoids[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 213-218. DOI: 10.13422/j.cnki.syfjx.2015170213.
Biological Activity and Structure-Activity Relationship of Prenylated Flavonoids
is characterized by the presence of the prenyl side chain on the skeleton of flavonoids. According to the prenyl binding sites
number and type of constructions
prenylated flavonoids are divided into 3 prenylated flavonoids
5 prenylated flavonoids
6 prenylated flavonoids
8 prenylated flavonoids
multiple side-chain prenylated flavonoids
pyran ring prenylated flavonoids and lavender prenylated flavonoids. Prenylated flavonoids show a wide range of biological activities
particularly with significant efficacy in improving the differentiation of stem cells
anti-inflammatory and immunoregulation and cardiovascular protection
mitigating metabolic diseases and osteoporosis
neural protection
anti-tumor
anti-aging and reproductive function. There is a significant correlation between the chemical structure and biological activity of prenylated flavonoids. Therefore
the structure-activity relationship of prenylated flavonoids is particularly important
and provides a theoretical basis for the synthesis of new compounds and function prediction.