HE Jing, ZHANG Yu-juan, TIAN Li, et al. Influence of Micronization on Micromeritic Properties and Dissolution of Berberine Hydrochloride[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 5-8.
DOI:
HE Jing, ZHANG Yu-juan, TIAN Li, et al. Influence of Micronization on Micromeritic Properties and Dissolution of Berberine Hydrochloride[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 5-8. DOI: 10.13422/j.cnki.syfjx.2015180005.
Influence of Micronization on Micromeritic Properties and Dissolution of Berberine Hydrochloride
Objective: To compare micromeritic properties and dissolution of each ultrafine powder of berberine hydrochloride for improving its dissolution efficiency. Method: Berberine hydrochloride was crushed by vibration mill.Particle size
specific surface area and porosity of samples were detected.The crystal structure of ultrafine powder was analyzed by differential scanning calorimetry (DSC).In vitro dissolution of berberine hydrochloride power was investigated. Result: After crushed
the minium value of d0.9 (90% of particle size cumulative distribution) of berberine hydrochloride could reach 38.78 μm.In a word
specific surface area and porosity varied from grinding time
they significantly increased in 4 minutes;after 4 minute
they decreased with increasing of grinding time.DSC curve indicated that the product of crystallinity decreased in different extent.Dissolution test showed that dissolution effect of berberine hydrochloride powder improved by comparing with the original powder
dissolution effect of the 4 min powder by crushing was the best. Conclusion: After crushed by vibration mill
some powder properties and dissolution of berberine hydrochloride can improve
this study will give a theoretical guidance for clinical medication and formulation development of drugs.