HUANG Wei, XIONG Wei, TANG Can, et al. Influence of Platycodonis Radix and Achyranthis Bidentatae Radix in Xuefu Zhuyu Tang on Tissue Distribution of Paeoniflorin[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 85-88.
DOI:
HUANG Wei, XIONG Wei, TANG Can, et al. Influence of Platycodonis Radix and Achyranthis Bidentatae Radix in Xuefu Zhuyu Tang on Tissue Distribution of Paeoniflorin[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 85-88. DOI: 10.13422/j.cnki.syfjx.2015180085.
Influence of Platycodonis Radix and Achyranthis Bidentatae Radix in Xuefu Zhuyu Tang on Tissue Distribution of Paeoniflorin
Objective: To compare effect of different compatibility of Platycodonis Radix and Achyranthis Bidentatae Radix on tissue distribution of paeoniflorin in normal and blood stasis mice
preliminary study leading action of Platycodonis Radix and Achyranthis Bidentatae Radix. Method: Normal and blood stasis mice were gavaged with Xuefu Zhuyu Tang
lacked Platycodonis Radix or Achyranthis Bidentatae Radix parties.Mice were killed after 30 minutes
whole blood collected
the brain
heart
liver
spleen
lung and kidney were removed.HPLC was employed to determine the content of paeoniflorin with mobile phase of acetonitrile-water (16:84)
detection wavelength at 230 nm and geniposide as internal standard. Result: After normal mice being gavaged with Xuefu Zhuyu Tang full party
single lacked Platycodonis Radix party
single lacked Achyranthis Bidentatae Radix party
lacked Platycodonis Radix and Achyranthis Bidentatae Radix party
the content of paeoniflorin in lung were 0.010 2
0.005 8
0.091 0
0.037 3 μg· g-1
those in kidney were 0.122 2
0.052 0
0.144 0
0.065 0 μg· g-1
but paeoniflorin were unchecked in the brain
heart
liver and spleen.After blood stasis mice being gavaged with Xuefu Zhuyu Tang full party
single lacked Platycodonis Radix party
the content of paeoniflorin in lung were 0.076 4
0.042 0 μg· g-1
those in kidney were 0.335
0.210 μg· g-1
but it was unchecked in the brain
heart
liver and spleen.After blood stasis mice being gavaged with Xuefu Zhuyu Tang single lacked Achyranthis Bidentatae Radix party
lacked Platycodonis Radix and Achyranthis Bidentatae Radix party
the content of paeoniflorin in lung were 0.274 7
0.019 7 μg· g-1
those in kidney were 0.467 1
0.149 0 μg· g-1
it almost were unchecked in the brain
heart
liver and spleen. Conclusion: Making comparison based on Xuefu Zhuyu Tang lacked Platycodonis Radix and Achyranthis Bidentatae Radix party
Platycodonis Radix can increase the content of paeoniflorin in the lung and kidney in normal mice
Platycodonis Radix can more significantly increase the content of paeoniflorin in the lung than that in the kidney in blood stasis mice.Achyranthis Bidentatae Radix can decrease the content of paeoniflorin in the lung and kidney in normal mice
it can increase the content of paeoniflorin in the lung and kidney in blood stasis mice
it also can make distribution of paeoniflorin in the heart
liver
spleen in blood stasis mice.This study confirms Platycodonis Radix and Achyranthis Bidentatae Radix have effect of leading action.Leading sites of Platycodonis Radix and Achyranthis Bidentatae Radix are not single.
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Related Author
ZHANG Feng-hua
LI Yan
PENG Liang
JIANG Lifeng
WANG Sheng
WANG Ge
YU Xiaolin
YAO Yulin
Related Institution
Henan University of Chinese Medicine
Fuwai Central China Cardiovascular Hospital/Henan Provincial People's Hospital
The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital
Third Affiliated Hospital of Henan University of Chinese Medicine