Effect of Sanhuang Huoluo Formula on Blood Glucose, Renal Function, SREBP-1c and SREBP-2c of Diabetic Nephropathy Rats

YAO Yu-hong

doi:10.13422/j.cnki.syfjx.2015180155

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Effect of Sanhuang Huoluo Formula on Blood Glucose, Renal Function, SREBP-1c and SREBP-2c of Diabetic Nephropathy Rats

更新时间：2024-01-04

- Effect of Sanhuang Huoluo Formula on Blood Glucose, Renal Function, SREBP-1c and SREBP-2c of Diabetic Nephropathy Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 18, Pages: 155-158(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015180155
  CLC： R285.5
- Published：2015
- 稿件说明：
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YAO Yu-hong. Effect of Sanhuang Huoluo Formula on Blood Glucose, Renal Function, SREBP-1c and SREBP-2c of Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 155-158.
DOI：

YAO Yu-hong. Effect of Sanhuang Huoluo Formula on Blood Glucose, Renal Function, SREBP-1c and SREBP-2c of Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 155-158. DOI： 10.13422/j.cnki.syfjx.2015180155.

摘要

目的: 观察三黄活络方对早期糖尿病肾病大鼠血糖

肾功能

固醇调节元件结合蛋白-1c(SREBP-1c)

SREBP-2c的影响。方法: 采用链脲佐菌素诱导的方法建立大鼠糖尿病模型

将糖尿病模型成功的大鼠随机分为模型组、阳性药组及三黄活络方低、中、高剂量组

其它组行切除大鼠右侧肾脏术后ig

阳性药组给予1.3 mg·kg-1盐酸贝那普利

三黄活络方低剂量组、中剂量组和高剂量组均给予中药颗粒

剂量分别为5

30 g·kg-1。正常组和模型组均ig给予蒸馏水

所有组均连续ig 8周。观察大鼠血糖(GLU)

糖化血红蛋白(HbA1c)

血尿素氮(BUN)

肌酐(SCr)

尿蛋白(Pro)

SREBP-lc

SREBP-2c的水平。结果: 与正常组比较

模型组的GLU和HbA1c均显著性升高(P<0.01)

阳性药组、各三黄活络组的GLU和HbA1c也均显著性升高(P<0.01);与模型组比较

阳性药组、各三黄活络组的GLU均降低(P<0.01)

阳性药组、中、高剂量组的HbA1c均降低(P<0.01)

低剂量组的HbA1c降低(P<0.05)。与正常组比较

模型组的SCr

BUN

Pro

SREBP-1c及SREBP-2c均显著性升高(P<0.01)

阳性药组和各三黄活络组的SCr

BUN

Pro

SREBP-1c及SREBP-2c也均显著性升高(P<0.01)。与模型组对比

阳性药组、各三黄活络组的SCr

BUN

Pro

SREBP-1c及SREBP-2c均较低(P<0.01)。与阳性药组对比

低剂量组的SCr

BUN

Pro

SREBP-1c及SREBP-2c均较高(P<0.01)

中剂量组的的SCr

BUN

Pro

SREBP-1c及SREBP-2c均较高(P<0.05)。结论: 三黄活络方能改善糖尿病肾病大鼠SCr

BUN

Pro

SREBP-1c及SREBP-2c水平

对糖尿病肾病大鼠肾损伤有一定的保护作用。

Abstract

Objective: To observe the effect of Sanhuang Huoluo formula on blood glucose

renal function

sterol regulating element binding protein-1c (SREBP-1c) and SREBP-2c of diabetic nephropathy rats. Method: The diabetic model was induced by streptozotocin. The rats in the successfully established diabetic model were randomly divided into the model group

the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups. After other groups took the resection of the right kidney

the positive drug group was given 1.3 mg· kg-1 of benazepril hydrochloride

Sanhuang adjustable low dose group

middle dose group and high dose group were orally given Chinese medicine granules with doses of 5

30 g· kg-1

respectively. Both of the normal group and the model group mice were orally given distilled water

and all of the groups orally given drugs for 8 weeks in a row. Blood glucose (GLU)

glycosylated hemoglobin (HbA1c)

blood urea nitrogen (BUN)

creatinine (SCr)

urine protein (Pro)

SREBP-lc

SREBP-2c in rats were observed. Result: Compared with the normal group

GLU and HbA1c of the model group were significantly higher (P<0.01)

GLU and HbA1c of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were also significantly higher (P<0.01). Compared with the model group

GLU of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were lower (P<0.01)

HbA1c of the positive drug group and Sanhuang Huoluo formula medium and high doses groups were lower (P<0.01)

HbA1c of the Sanhuang Huoluo formula low dose group was lower (P<0.05). Compared with the normal group

SCr

BUN

Pro

SREBP-lc and SREBP-2c of the model group were significantly higher (P<0.01)

and SCr

BUN

Pro

SREBP-lc and SREBP-2c of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were also significantly higher (P<0.01). Compared with the model group

SCr

BUN

Pro

SREBP-lc and SREBP-2c of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were lower (P<0.01). Compared with the positive drug group

SCr

BUN

Pro

SREBP-lc and SREBP-2c of the Sanhuang Huoluo formula low dose group were higher (P<0.01)

and SCr

BUN

Pro

SREBP-lc and SREBP-2c of the Sanhuang Huoluo formula medium dose group were higher (P<0.05). Conclusion: Sanhuang Huoluo formula can improve level of SCr

BUN

Pro

SREBP-lc and SREBP-2c in diabetes nephropathy rats

with a certain protective effect on renal damage in rats of diabetic nephropathy rats.

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Related Institution

Shijiazhuang Ping’an Hospital

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