Objective: To investigate the curative efficacy of Yimucao injection combined with carboprost tromethamine in preventing cesarean section postpartum hemorrhage and on levels of fibrinogen(FIB) and D-dimer. Method: One hundred and forty cases of obstetric indications for cesarean section and with high risk factors of uterine inertia were divided into 2 groups equally according to random number table:the control group(n=70) and the observation group (n=70). After delivery of the fetus in cesarean section

the control group was treated with uterus injection of carboprost tromethamine

while the observation group was treated with intramuscular injection of Yimucao injection and uterus injection of carboprost tromethamine. Their 2

24 h postoperative blood loss

the incidence of postpartum hemorrhage

duration of uterine contraction after the drug injection

lowering speed of uterine bottom after delivery

duration of lochia

level of FIB

D-dimer and adverse reactions were observed and compared. Result: In comparison with the control group

2

24 h postoperative blood loss were significantly lower (234.5±50.2) VS (356.2±51.5)

(309.7±64.5) VS (443.3±68.6) mL and the incidence of postpartum hemorrhage was significantly lower (4.3% VS 14.3%) in the observation group (both P<0.05). After the drug injection

the observation group had a significantly longer duration of uterine contraction (3.43±1.03) VS (1.62±0.54) h

quicker lowering speed of uterine bottom (1.15±0.24) VS (0.56±0.13) cm· d-1 and shorter duration of lochia (14.8±4.7) VS (21.5±6.2) d than those in the control group (all P<0.05). And level of FIB (3.50±0.24) VS (4.61±0.42) g· L-1

D-dimer (1.21±0.23) VS (3.47±0.29) mg·L-1 in the observation group was respectively lower than that in the control group after the treatment (both P<0.05). During the treatment

there was no case of severe adverse reaction and no statistical difference in inter-group comparison of the incidence of adverse reactions (18.6% VS 21.4%). Conclusion: Therapy of Yimucao injection combined with carboprost tromethamine was effective in the prevention of cesarean section postpartum hemorrhage

and could effectively reduce postoperative blood loss

decrease the incidence of postpartum hemorrhage

lengthen duration of uterine contraction

promote postpartum recovery and mitigate high blood coagulation

with minor adverse reactions. It is worth further studies in clinic.