Effect of Buzhong Yiqi Tang in Treating 38 Cases of Spleen and Kidney Deficiency Type Recurrent Spontaneous Abortion Caused by Negative Blocking Antibody

TIAN Dan; DAI Hai-qing; LI Zhao-ping; ZHENG Xin-lian

doi:10.13422/j.cnki.syfjx.2015180167

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Effect of Buzhong Yiqi Tang in Treating 38 Cases of Spleen and Kidney Deficiency Type Recurrent Spontaneous Abortion Caused by Negative Blocking Antibody

更新时间：2024-01-04

- Effect of Buzhong Yiqi Tang in Treating 38 Cases of Spleen and Kidney Deficiency Type Recurrent Spontaneous Abortion Caused by Negative Blocking Antibody
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 18, Pages: 167-170(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015180167
  CLC： R271.9
- Published：2015
- 稿件说明：
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TIAN Dan, DAI Hai-qing, LI Zhao-ping, et al. Effect of Buzhong Yiqi Tang in Treating 38 Cases of Spleen and Kidney Deficiency Type Recurrent Spontaneous Abortion Caused by Negative Blocking Antibody[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 167-170.
DOI：

TIAN Dan, DAI Hai-qing, LI Zhao-ping, et al. Effect of Buzhong Yiqi Tang in Treating 38 Cases of Spleen and Kidney Deficiency Type Recurrent Spontaneous Abortion Caused by Negative Blocking Antibody[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 167-170. DOI： 10.13422/j.cnki.syfjx.2015180167.

摘要

目的: 观察补中益气汤加减治疗封闭抗体阴性所致复发性流产(脾肾两虚证)的临床疗效

及对血清白细胞介素-6(IL-6)

肿瘤坏死因子-α(TNF-α)

γ-干扰素(IFN-γ)

白细胞介素-10(IL-10)水平的影响。方法: 将73例患者采用随机按数字表法分为实验组38和对照组35例。对照组采用配偶淋巴细胞体外诱生免疫疗法

实验组加用补中益气汤加减

于准备受孕前3个月开始服用

妊娠后继续服用至妊娠16周。两组均随访至分娩。记录受孕

超过原流产孕周

孕周达超12周和足月分娩情况;进行治疗前后的脾肾两虚证评分;检测封闭抗体三项(抗CD3-BE

抗CD4-BE和抗CD8-BE)转阳情况;检测治疗前后血清IL-6

TNF-α

IFN-γ和IL-10水平。结果: 两组受孕率和超过原流产孕周率比较差异无统计学意义

实验组孕周达超12周率和足月分娩率均高于对照组(P<0.05);治疗后实验组抗CD3-BE和抗CD8-BE阳转率高于对照组(P<0.05);治疗后实验组TNF-α

和IFN-γ水平低于对照组

IL-6和IL-10水平高于对照组(P<0.01);治疗后实验组总有效率为89.47%

优于对照组的71.43%(P<0.05)。结论: 补中益气汤加减联合配偶淋巴细胞体外诱生免疫疗法治疗封闭抗体阴性所致复发性流产

能促进封闭抗体转阳、提高妊娠分娩率、减轻临床症状

临床疗效显著。

Abstract

Objective: To observe the clinical effect of modified Buzhong Yiqi Tang in treating recurrent spontaneous abortion (spleen kidney deficiency type) caused by negative closed antibody and its effect on levels of serum interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

γ-interferon (IFN-γ)

interleukin-10 (IL-10). Method: Seventy-three patients were randomly divided into the experimental group (38 cases) and control group (35 cases) according to the number table method. For control group

patients took spouse in vitro lymphocyte-induce immune therapy. In addition to the therapy of control group

experimental group was given Buzhong Yiqi Tang from the 3rd month before preganecy to the 16 weeks of gestation. For the two groups

they were all followed up until delivery. Conception

the number of weeks exceeding the original gestational weeks

gestational age up to 12 weeks and term birth were recorded. The spleen kidney deficiency syndrome before and after treatment were scored. The conversion of three negative closed antibody (anti-CD3-BE

anti-CD4-BE and anti-CD8-BE) to positive were detected. The levels of serum IL-6

TNF-α

IFN-γ and IL-10 before and after treatment were tested. Result: There was no statistical significance in difference between pregnancy rate and the number of weeks exceeding the original gestational weeks in two groups. The gestational age up to 12 weeks and the rate of term birth in experimental group were superior to these data in control group (P<0.05). After treatment

positive conversion rate of anti-CD3-BE and anti-CD8-BE in experimental group were higher than these data in control group (P<0.05). Levels of TNF-α and IFN-γ in experimental group were superior to these in control group

while the IL-6 and IL-10 were higher than the standards in control group (P<0.01). The total effective rate was 89.47% in experimental group

which was better than 71.43% in control group (P<0.05). Conclusion: Modified Buzhong Yiqi Tang combined with in vitro spouse lymphocyte-induce immune therapy can treat recurrent spontaneous abortion caused by negative closed antibody

promote the positive conversion of closed antibodies

enhance the rate of childbirth pregnancy and relieve clinical symptoms. It has distinct clinical curative effect.

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