Effect of Bushen Quhan Zhiwang Decoction in Treating 65 Cases with Kidney Deficiency and Blood Stasis Type Knee Osteoarthritis

LLU Ke-jun; MA Cheng-de; WU Zhen

doi:10.13422/j.cnki.syfjx.2015180175

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Effect of Bushen Quhan Zhiwang Decoction in Treating 65 Cases with Kidney Deficiency and Blood Stasis Type Knee Osteoarthritis

更新时间：2024-01-04

- Effect of Bushen Quhan Zhiwang Decoction in Treating 65 Cases with Kidney Deficiency and Blood Stasis Type Knee Osteoarthritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 18, Pages: 175-178(2015)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2015180175
  CLC： R274.9
- Published：2015
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LLU Ke-jun, MA Cheng-de, WU Zhen. Effect of Bushen Quhan Zhiwang Decoction in Treating 65 Cases with Kidney Deficiency and Blood Stasis Type Knee Osteoarthritis[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 175-178.
DOI：

LLU Ke-jun, MA Cheng-de, WU Zhen. Effect of Bushen Quhan Zhiwang Decoction in Treating 65 Cases with Kidney Deficiency and Blood Stasis Type Knee Osteoarthritis[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 175-178. DOI： 10.13422/j.cnki.syfjx.2015180175.

摘要

目的: 观察补肾祛寒治尪汤治疗肾虚血瘀证膝骨性关节炎(KOA)的临床疗效及对血清和关节液白细胞介素-6(IL-6)

肿瘤坏死因子-α(TNF-α)水平的影响。方法: 采用随机按数字表法将137例肾虚血瘀型KOA患者分为对照组68例和治疗组各69例。期间对照组脱落3例

治疗组脱落4例。对照组口服盐酸氨基葡萄糖片

480 mg/次

3次/d

治疗组在对照组治疗的基础上采用补肾祛寒治尪汤内服

1剂/d。两组疗程均为6周。采用西部安大略麦克马斯特大学骨关节炎指数可视化量表(WOMAC)对两组患者的症状体征进行评分

检测两组患者治疗前后的血液流变学指标及血清和关节液白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平。结果: 对照组临床有效率为87.69%

治疗组为96.92

治疗组优于对照组(P<0.05);治疗后治疗组日常活动、关节僵硬、疼痛和总积分均低于对照组(P<0.01);治疗组治疗后血液流变学各项指标改善均优于对照组(P<0.01);治疗后治疗组血清和关节液中IL-6和TNF-α水平均明显低于对照组(P<0.01)。结论: 补肾祛寒治尪汤治疗肾虚血瘀型KOA患者临床疗效显著

其作用机制可能与其改善血液循环

减少炎症反应等作用有关。

Abstract

Objective: To observe the clinical efficacy of oral administration of Bushen Quhan Zhiwang decoction in the treatment of kidney deficiency and blood stasis type knee osteoarthritis(KOA) and its effect on levels ofinterleukin-6(IL-6) and tumor necrosis factor(TNF-α) in serum and synovial fluid. Method: One hundred thirty-seven patients with kidney deficiency and blood stasis type KOA were divided into control group(68 cases)and treatment group (69 cases) by random number table.Three and four cases were dropped during treatment from control group and treatment group respectively.For control group

patients took glucosamine hydrochloride tablets (480 mg/time

3 times/d).In addition to the therapy of control group

patients in treatment group were orally administered with Bushen Quhan Zhiwang decoction(1 dose/d

bid) and lontophoresis(30 min/time

1 time/d). Course of treatment were 6 weeks for both groups.The Western Ontario and McMaster Universities(WOMAC) score was used to evaluated the symptoms and signs of patients in two groups before and after treatment.The hemorheological indexes and levels of IL-6 and TNF-α in the serum and synovial fluid were detected before and after treatment. Result: The effective rate of control group was 87.69%

which was superior to 96.92% of treatment group(P<0.05). The scores for daily activities

joint stiffnessand pain and total score of WOMAC of treatment group were lower than those of control group(P<0.01).The hemorheological indexes in treatment group were superior to those in control group(P<0.01).The levels of IL-6 and TNF-α in the serum and synovial fluid in treatment group were lower than that in control group(P<0.01). Conclusion: Bushen Quhan Zhiwang decoction for oral administration shows significant efficacyin the treatment of kidney deficiency and blood stasis type KOA

and its mechanism may be related with improving blood circulation and reducing inflammatory reaction.

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