Drugs can play its efficacy only when their concentration accumulates to a certain degree at target sites. The accumulated concentration is not only related to the drug dosage

but also closely correlated with the processes of absorption

distribution

metabolism

and excretion in organisms. Since the pharmacokinetic behaviors of drugs may significantly change in pathological conditions

it is of great significance to study drug pharmacokinetics in disease conditions and rationally design clinical dosage regimens. Therefore

to provide certain reference of rational clinical drug administration of traditional Chinese medicines(TCMs) and their preparations

efforts shall be made to analyze the impacts of some clinical common diseases on the absorption

distribution

metabolism

and excretion of TCMs and the impacts of different lesions and their interactions on the metabolic process of TCMs.