SUN Ying, LIU Hong-li, CUI Wen-wen, et al. Protective Effect of Traditional Chinese Medicine on Islet Beta Cells[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 215-219.
DOI:
SUN Ying, LIU Hong-li, CUI Wen-wen, et al. Protective Effect of Traditional Chinese Medicine on Islet Beta Cells[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(18): 215-219. DOI: 10.13422/j.cnki.syfjx.2015180215.
Protective Effect of Traditional Chinese Medicine on Islet Beta Cells
Islet beta cell dysfunction and decrease play an important role in the occurrence and development of type 2 diabetes mellitus(T2DM). The effect of traditional Chinese medicine (TCM) on the protection of islet beta cells was recognized and plays a crucial role in the prevention and control of type 2 diabetes. The protective mechanism of TCMs' extracts
monomer and compounds to islet beta cells were summarized to define their effect in protecting islet beta cells and treating T2DM. Some TCMs can promote islet beta cell proliferation
reduce islet beta cells apoptosis
and protect islet beta cells indirectly by promoting islet beta cell proliferation
reducing islet beta cell apoptosis
improving serum and pancreatic tissue oxidative stress
improving islet cell insulin resistance
improving the level of glucagon like peptide-1(GLP-1)
improving pancreas microcirculation
regulating autophagy level. Because of the complexity of the traditional Chinese medicine ingredients and compound formula
their protective effect on islet beta cells involves a variety of targets and mechanisms. Besides
under the guidance of general concept of TCMs
TCMs have a higher safety in treating T2DM. Therefore
TCMs have a broad prospect to protect islet beta cells. With the development of biotechnology
it is possible to screen out new diabetes drugs from TCMs.
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