MA Cong, XIONG Yao-kun, MA Shi-yu, et al. Urine and Bile Excretion of Senkyunolide I in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(19): 75-79.
DOI:
MA Cong, XIONG Yao-kun, MA Shi-yu, et al. Urine and Bile Excretion of Senkyunolide I in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(19): 75-79. DOI: 10.13422/j.cnki.syfjx.2015190075.
Urine and Bile Excretion of Senkyunolide I in Rats
Objective: To study excretion characteristics of senkyunolide I in urine and bile by intravenous injection and intragastric administration
respectively. Method: Rats were intravenous injected and intragastric administrated with senkyunolide I at a dose of 72 mg·kg-1
respectively.The urine and bile were collected at different time points.The concentrations of senkyunolide I in urine and bile were measured by HPLC-VWD
detection wavelength was set at 278 nm
mobile phase consisted of acetonitril-water (containing 0.1% formic acid) for gradient elution. Result: After intragastric administration and intravenous injection
cumulative excretion of senkyunolide I in 48 h were (179.8±33.68)
(264.8±87.28) μg in urine
cumulative excretion percentages were calculated to be (0.77±0.15)% and (1.35±0.26)%
respectively;cumulative excretion of senkyunolide I in 36 h were (359.4±75.66)
(426.3±140.90) μg in bile
cumulative excretion percentages were calculated to be (1.22±0.49)% and (1.72±0.59)%
respectively. Conclusion: Prototype is not main elimination form of senkyunolide I in rats' urine and bile
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Related Author
CARTIERA Kurban
WANG Changhong
XU Nan
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Qing WANG
Related Institution
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, The First Affiliated Hospital of Xinjiang Medical University
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