Objective: To observe the effects of Linggui Zhugan Tang combined with Shengmai San in treating senility frequent ventricular premature beat (FVPB) as well as its influences to heart rate variability (HRV) and heart rate turbulence (HRT). Method: One hundred and eight patients with frequent ventricular premature beat were randomly divided into control group (53 cases) and observation group (55 cases) according to their order of hospitalization. Patients in control group received about 1 minute of esmolol hydrochloride intravenous injection

0.5 mg·kg-1·min-1

with a maintenance dose of 0.05 mg·kg-1·min-1 for intravenous drip. Based on the treatment of control group

patients in observation group also received Linggui Zhugan Tang combined with Shengmai San. Courses of treatment in two groups were both 4 weeks. Before and after treatment

times of ventricular premature beat

HRV and HRT were recorded by 24 hours' ambulatory electrocardiogram. HRV included 4 indicators:24 hours' standard deviation of normal to normal RR intervals (SDNN)

standard deviation of 5 min average normal RR intervals in 24 h (SDANN)

root mean square successive differences (RMSSD) in normal R-R intervals

and percentage of differences between adjacent normal RR intervals exceeding 50 milliseconds

PNN50.HRT included 2 indicators:turbulence onset (TO) and turbulence slope (TS). And scores of main symptoms were also graded. Result: Total effective rate for premature beat was 92.73% in observation group

and 77.36% in control group. Thus

the efficacy in observation group was better than that of control group for comparison (P<0.05). After treatment

the SDNN

SDANN

RMSSD and PNN50 in observation group were superior to these in control group (P<0.05

P<0.01). TS in two groups went up slightly compared with the data before therapy

while the increase in observation group was more obvious (P<0.01). The number of cases with ventricular premature beat in observation group was less than that in control group (P<0.05)

and the reducing number of ventricular premature beat in observation group was more than that in control group(P<0.05). After therapy

the main symptom scores in observation group were lower than these in control group (P<0.01). The decrease of main symptom scores in observation group were superior to that in control group (P<0.01). Conclusion: Linggui Zhugan Tang combined with Shengmai San for senility frequent ventricular premature beat could improve HRV and HRT

reduce the incidence of ventricular premature beat

and improve the clinical symptoms

with better clinical efficacy compared with western medicine alone.