Objective: To study the curative effect of additional Sini Tang combined with prucalopride in treating patients with Yang deficiency type chronic constipation

in order to offer a new therapeutic schedule for improving the clinical curative effect and reduce adverse drug reactions. Method: Totally 278 cases of patients with Yang deficiency type chronic constipation treated in our hospital from October 2012 to November 2014 were taken as the research objects

and randomly divided into western medicine group and Chinese combined with western medicine group

each group was 139 cases. The western medicine group were treated by oral prucalopride

the Chinese combined with western medicine group were treated by oral prucalopride and additional Sini Tang

both groups were treated for 12 weeks.The changes of clinical symptoms

Chinese medicine symptom score and colon transmission test score of two groups before and after treatment were observed

and the adverse reactions in the process of treatment were compared and analyzed. Result: Various symptom scores of two groups after treatment were significantly lower than that before the treatment (P<0.05)

and the comparison between the groups showed that the clinical symptoms and clinical symptom scores of Chinese combined with western medicine group were significantly lower than that of western medicine group (P<0.05). The colon transmission test showed that the number of normal patients of Chinese combined with western medicine group was significantly higher than that of western medicine group

with significantly fewer moderate patients (P<0.05). After the treatment

the improvement of anal canal resting pressure

anal canal maximum systolic blood pressure

the length of the anal sphincter and the continuous extrusion time of patients in Chinese combined with western medicine group were more significant than that of the western medicine group (P<0.05).After the treatment

compared with western medicine group

the cure rate of patients in Chinese combined with western medicine group was obviously increase and no efficiency patients were significantly decreased (P<0.05).During the treatment

the incidence of adverse reactions of Chinese combined with western medicine group was obviously lower than that of the control group (P<0.05)

the differences were statistically significant. Conclusion: Combined therapy with additional Sini Tang in treating Yang deficiency type chronic constipation can effectively increase prucalopride's effect in relieving clinical symptoms

improve the clinical curative effect

and significantly reduce the occurrence of adverse reactions.