WANG Zhen, JU Jian-qing, LI Yun-lun. Systematic Evaluation and Trial Sequential Analysis of Shenmai Injection on Mortality Rate of Patients with Acute Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(19): 189-193.
DOI:
WANG Zhen, JU Jian-qing, LI Yun-lun. Systematic Evaluation and Trial Sequential Analysis of Shenmai Injection on Mortality Rate of Patients with Acute Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(19): 189-193. DOI: 10.13422/j.cnki.syfjx.2015190189.
Systematic Evaluation and Trial Sequential Analysis of Shenmai Injection on Mortality Rate of Patients with Acute Myocardial Infarction
Objective: To systematically assess the efficacy of Shenmai injection on the mortality rate of patients with acute myocardial infarction (AMI). Method: Randomized controlled trials for evaluating Shenmai injection for AMI patients with the mortality rate as an outcome were collected from electronic databases for a systematic evaluation and meta-analysis. Besides
a cumulative meta-analysis according to the year of publication was conducted
and trial sequential analysis (TSA) was also adopted to test their results. Result: Sixteen qualified trials were included. Meta-analysis and cumulative meta-analysis indicated that Shenmai injection can decrease the mortality rate of AMI patients
with RR=0.61
99%CI (0.43
0.85)
RD=-0.06
99%CI (-0.09
-0.03)
NNT≈15.3.TSA further verified the results. Conclusion: Shenmai injection can decrease the mortality rate of patients with AMI. Due to the limitations of the study
clinical trials with rational design and strict execution shall be carried out in the future to provide more reliable evidence.
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