XING Yu-feng, TONG Guang-dong, ZHOU Da-qiao, et al. Effects of Shugan Xiaozhi Decoction on Blood Lipid Indicators in Non-alcoholic Steatohepatitis Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(20): 141-144.
DOI:
XING Yu-feng, TONG Guang-dong, ZHOU Da-qiao, et al. Effects of Shugan Xiaozhi Decoction on Blood Lipid Indicators in Non-alcoholic Steatohepatitis Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(20): 141-144. DOI: 10.13422/j.cnki.syfjx.2015200141.
Effects of Shugan Xiaozhi Decoction on Blood Lipid Indicators in Non-alcoholic Steatohepatitis Rats
Objective: To observe the effects of Shugan Xiaozhi decoction on blood lipid indicators of non-alcoholic steatohepatitis rats. Method: Sixty Wistar male rats were randomly divided into control group
hyper-lipidemia model group
fenofibrate group (0.1 g·kg-1·d-1)
Shugan Xiaozhi decoction high dose group
medium dose group and low dose group (high
medium and low doses refer to four times
two times and one time equivalent to the adult dose). All other groups except the control group were given with high fat diet to copy non-alcoholic steatohepatitis rats model
and received corresponding medicine at the same time
but the control group and hyper-lipidemia model group received distilled water. After 8 weeks
blood lipid cholesterol (TC)
triglyceride (TG)
free fatty acid (FFA)
liver function alanine transaminase (ALT)
aspertate aminotransferase (AST) and blood rheology were detected. Result: Compared with the model group
the levels of following indicators were obviously decreased in Shugan Xiaozhi decoction high dose group
medium dose group and low dose group:TG
TC
FFA
whole blood viscosity (low shear)
plasma viscosity
red blood cell aggregation index
ALT
and AST (P<0.01). Conclusion: Shugan Xiaozhi decoction has the effect of lowering blood lipid levels
protecting liver and diminishing enzymes in non-alcoholic steatohepatitis rats.