ZHANG Ting, GAO Yan-bin, YI Wen-ming. Wenshen Jianpi and Huayu Tongluo Methods in Treating Clinical-stage Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(20): 200-203.
DOI:
ZHANG Ting, GAO Yan-bin, YI Wen-ming. Wenshen Jianpi and Huayu Tongluo Methods in Treating Clinical-stage Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(20): 200-203. DOI: 10.13422/j.cnki.syfjx.2015200200.
Wenshen Jianpi and Huayu Tongluo Methods in Treating Clinical-stage Diabetic Nephropathy
Objective: To observe the therapeutic effects of method for warming the kidney and strengthening the spleen
and dispersing blood stasis and promoting collaterals in the treatment of clinical-stage diabetic nephropathy (DN). Method: Fifty eligible DN patients were randomly divided into the treatment group (25 patients) and control group (25 patients). Besides the routine therapy including controlling diet
lowing blood glucose and orally taking fosinopril (10 mg daily)
the treatment group was also given traditional Chinese medicine(TCM) for warming the kidney and strengthening the spleen
and dispersing blood stasis and promoting collaterals for 12 weeks. The changes in quantitation of 24-hour urinary protein (UP)
serum creatinine (SCr)
endogenous creatinine clearance rate (CCr)
TCM syndrome score were observed in the patients. Result: The total effective rate of the treatment group was 80.0%
and that of control group was 56.0%. The effect of treatment group was better than the control group in lowing 24 h UP (P<0.05)
reducing SCr (P<0.05)
increasing CCr (P<0.05) and improving renal function (P<0.05). Conclusion: The method of warming the kidney and strengthening the spleen
and dispersing blood stasis and promoting collaterals can effectively abate and treat clinical-stage DN.
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