Effect of Different Processed Products of Cimicifugae Rhizoma in Gastrointestinal Function of Spleen-qi Deficiency Animals

ZHU Jing; ZHONG Ling-yun; GONG Qian-feng; LIU Li-ping; YU Huan; CHEN Rui-lin

doi:10.13422/j.cnki.syfjx.2015210001

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Effect of Different Processed Products of Cimicifugae Rhizoma in Gastrointestinal Function of Spleen-qi Deficiency Animals

更新时间：2024-01-04

- Effect of Different Processed Products of Cimicifugae Rhizoma in Gastrointestinal Function of Spleen-qi Deficiency Animals
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 21, Pages: 1-4(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015210001
  CLC： R285.5
- Published：2015
- 稿件说明：
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ZHU Jing, ZHONG Ling-yun, GONG Qian-feng, et al. Effect of Different Processed Products of Cimicifugae Rhizoma in Gastrointestinal Function of Spleen-qi Deficiency Animals[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 1-4.
DOI：

ZHU Jing, ZHONG Ling-yun, GONG Qian-feng, et al. Effect of Different Processed Products of Cimicifugae Rhizoma in Gastrointestinal Function of Spleen-qi Deficiency Animals[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 1-4. DOI： 10.13422/j.cnki.syfjx.2015210001.

摘要

目的: 观察升麻不同炮制品对脾气虚小鼠和脾气虚大鼠胃肠功能的影响。方法: 采用三因素复合法复制脾气虚实验动物模型

造模成功后

将动物随机分成空白组、脾气虚模型组、生升麻组、蜜升麻组和蜜麸升麻组

给药14 d后测定小鼠胃残留率和小肠推进率、大鼠血清胃泌素(GAS)含量和血浆胃动素(MTL)含量。结果: 与脾气虚模型组比较

升麻生品及炮制品皆能显著降低小鼠胃残留率

生品组、蜜升麻组、蜜麸升麻组的胃残留率分别为(57.87±9.01)%

(52.01±8.76)%

(49.49±7.88)%;并显著增加肠推进率

生品组、蜜升麻组、蜜麸升麻组小肠推进率分别为(38.89±9.06)%

(43.27±8.97)%

(44.03±9.76)%。模型组给药干预后能显著提高大鼠血清GAS含量

生品组、蜜升麻组、蜜麸升麻组的GAS质量浓度分别为(59.36±8.17)

(64.53±9.02)

(72.93±10.00) ng·L-1;极显著提高血浆MTL含量

生品组、蜜升麻组、蜜麸升麻组的MTL质量浓度分别为(330.12±19.37)

(340.24±18.98)

(343.76±21.03) ng·L-1。蜜麸升麻组的各项指标最接近空白组。结论: 升麻生品和炮制品均能促进脾气虚动物胃肠功能的恢复

且樟帮特色蜜麸升麻的治疗作用优于生升麻和蜜升麻。

Abstract

Objective: To observe effect of different processed products of Cimicifugae Rhizoma in gastrointestinal function of spleen-qi deficiency animals. Method: Spleen-qi deficiency syndrome was induced in animals by compound methods which including rhubarb

exhaust and hunger.Spleen-qi deficiency animals were randomly divided into the blank group

model group and drug delivery group.After 14 days of administration

gastric emptying rate and intestinal propulsion rate of mice

gastrin and motilin content of rats were determined. Result: Processed products of Cimicifugae Rhizoma can significantly reduce gastric residual rate and a significant increase in intestinal propulsion rate by comparing with the model group.After administration intervention of the model group

contents of serum gastrin were significantly improved and contents of plasma motilin were significantly increased.Each index of the group of Cimicifugae Rhizoma processed with honey bran was the closest to the blank group. Conclusion: Processed products of Rhizoma Cimicifugae can promote recovery gastrointestinal function of spleen-qi deficiency animals.Treatment effect of processing of stir-frying with honey bran for Cimicifugae Rhizoma is the best.

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