ZHAO Chun-cao, LI Jie, WANG Ying-feng, et al. Screening Pharmaceutical Excipients of Suspending Agent for Notoginseng Radix et Rhizoma Powder Floating in Sanqi Yishen Granules[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 5-9.
DOI:
ZHAO Chun-cao, LI Jie, WANG Ying-feng, et al. Screening Pharmaceutical Excipients of Suspending Agent for Notoginseng Radix et Rhizoma Powder Floating in Sanqi Yishen Granules[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 5-9. DOI: 10.13422/j.cnki.syfjx.2015210005.
Screening Pharmaceutical Excipients of Suspending Agent for Notoginseng Radix et Rhizoma Powder Floating in Sanqi Yishen Granules
Objective: To optimize excipients combination of suspending agent for Sanqi Yishen granules. Method: Sodium carboxymethyl cellulose(CMC-Na)-dextrin
CMC-Na-starch
gum arabic-dextrin
hydroxypropyl methyl cellulose(HPMC)-starch
gum tragacanth powder-starch
sodium carboxymethyl starch(CMS-Na)-mannitol
PVP-S630-mannitol were chosen as suspending agents
regarded sedimentation time
sedimentation volume ratio
preparation feasibility and texture of liquid as indexes
fuzzy mathematics method was adopted to optimize excipient combination of suspending agents to make the raw powder of Notoginseng Radix et Rhizoma suspend and float well in liquid for ensuring accurate medication. Result: The best excipient combination of suspending agents for Sanqi Yishen granules was a mixture of 5%CMC-Na and 45% starch
and there are 40.5% of people who think it was‘very good’. Conclusion: Using CMC-Na-Starch as excipient combination of suspending agent for Sanqi Yishen granules can make sedimentation volume ratio of the raw powder achieve optimum with the best texture of liquid
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