Effect of Processing Degreasing on Main Ingredients and Efficacy of

WANG Peng-fei; XU Run-chun; LI Jiang-wei; ZHANG Yu-juan

doi:10.13422/j.cnki.syfjx.2015210020

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Effect of Processing Degreasing on Main Ingredients and Efficacy of

更新时间：2024-01-04

- Effect of Processing Degreasing on Main Ingredients and Efficacy of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 21, Pages: 20-23(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015210020
  CLC： R285.5
- Published：2015
- 稿件说明：
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WANG Peng-fei, XU Run-chun, LI Jiang-wei, et al. Effect of Processing Degreasing on Main Ingredients and Efficacy of [J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 20-23.
DOI：

WANG Peng-fei, XU Run-chun, LI Jiang-wei, et al. Effect of Processing Degreasing on Main Ingredients and Efficacy of [J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 20-23. DOI： 10.13422/j.cnki.syfjx.2015210020.

摘要

目的: 研究压榨美洲大蠊主要成分含量变化

并考察压榨美洲大蠊药材对CCl4致小鼠肝损伤保护作用

为该药材的临床应用提供参考。方法: 采用压榨法去除美洲大蠊油脂

利用茚三酮显色法和苯酚-硫酸法分别测定美洲大蠊药材中总氨基酸及总多糖含量

通过CCl4致小鼠急性肝损伤模型考察压榨美洲大蠊的药效。结果: 压榨美洲大蠊中油脂质量分数8.5%

总氨基酸及总多糖质量分数分别为13.334

21.06 mg·g-1

压榨美洲大蠊显著降低CCl4肝损伤小鼠的肝重系数

显著降低小鼠血清中丙氨酸转氨酶、天冬氨酸转氨酶含量。结论: 美洲大蠊经炮制减毒后

炮制品具有抗肝损伤药效。

Abstract

Objective: To investigate content change of main ingredients in Periplaneta americana by mechanical pressing

and investigate protective effect of pressed P. americana on liver injury in mice induced by CCl4. Method: Oil in P. americana was removed by mechanical pressing

ninhydrin colorimetry and phenol-sulfuric acid method were used to measure contents of total amino acids and total polysaccharides in P. americana

respectively.Efficacy of pressed P. americana was investigated by acute liver injury model of mice induced with CCl4. Result: Content of oil in pressed P. americana was 8.5%

contents of total amino acids and total polysaccharides were 13.334

21.06 mg·g-1

respectively.Pressed P. americana can significantly reduce liver weight coefficient of mice with liver injury and significantly decrease contents of alanine aminotransferase and aspartate aminotransferase in serum of mice. Conclusion: After processing attenuated

processed product of P. americana has efficacy of anti-liver injury.

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Related Author

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Related Institution

The First Clinical Medical College of Henan University of Chinese Medicine

School of Pharmacy， Henan University of Chinese Medicine

Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-yao

Henan Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yuyao，Henan Research Center for Special Processing Technology of Chinese Medicine，Henan University of Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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