SANG Ran, WANG Xiao-xiao, ZHU Yan-yan, et al. Serum Pharmacochemistry Analysis of Gushuling in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 78-81.
DOI:
SANG Ran, WANG Xiao-xiao, ZHU Yan-yan, et al. Serum Pharmacochemistry Analysis of Gushuling in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 78-81. DOI: 10.13422/j.cnki.syfjx.2015210078.
Serum Pharmacochemistry Analysis of Gushuling in Rats
Objective: To make a preliminary study on serum pharmacochemistry of Gushuling and investigate medicinal mechanism by a blood component analysis. Method: In vitro
in vivo HPLC of Gushuling
Gushuling without a certain receipt and every single receipt were established according to pharmacochemistry research method. And by comparing those HPLC
constituents absorbed into blood and components metabolized in blood were determined. Result: A total of 21 components in serum were determined after intragastric administration of Gushuling in rats
11 of them were prototype compound of preparation
4 of them were constituents generated by receipts interaction in vivo and the rest were metabolites. Conclusion: Components of Gushuling in rat serum are generated by interaction of all receipts
and the greatest contribution come from Epimedii Folium.This pharamcochemisty study of Gushuling provides a substance foundation for further pharmacodynamic mechanism of compound.
Analysis of Effect of Realgar with Different Compatibility Proportions on Transitional Constituents of Indigo Naturalis in Rat Serum Based on UPLC-Q-TOF-MS/MS
Serum Pharmacochemical Analysis of Periploca forrestii Rhizomes Based on UPLC-Q-TOF-MS
In Vitro and in vivo Component Identification of DanshenyinBased on UPLC-Q-TOF-MS/MS
Effect of Icariin on Steroid-induced Ferroptosis in Rat Bone Microvascular Endothelial Cells
Mechanism of Icariin in Regulating TGF-β1/Smad Pathway to Induce Autophagy in Human Bone Microvascular Endothelial Cells
Related Author
Min ZHANG
Qing-qing WU
Chen-hui LI
Ling-ling XU
Yuan-yuan ZHOU
Peng HUANG
He-ping HUANG
Juan YU
Related Institution
Anhui Province Key Laboratory of Chinese Medicinal Formula, School of Pharmacy, Anhui University of Chinese Medicine
Provincial Key Laboratory of Pharmaceutics in Guizhou Province, State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for Development and Application of Ethnic Medicine and Traditional Chinese Medicine, Ministry of Education, School of Pharmaceutical Sciences, Guizhou Medical University
Key Laboratory for Standardization of Chinese Medicines,Ministry of Education, Shanghai Key Laboratory for Compound Chinese Medicines,Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine