Objective: To investigate the anti-inflammatory effect and mechanism of New Bitongling compound(NBTL). Method: The 30 SD male rats were randomly divided into four groups:the model group

Bloven sustained release capsules positive control group(0.054 g·kg-1)

New Bitongling high-dose group and low-dose group(NBTLH

NBTLL

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2.75 g·kg-1). Rats were gave ig administered for 5 days

once a day. After 1 h of the last administration

models of increased capillary permeability (induced by histamine) were established

then dye in the skin was extracted after intravenous injection with Evans blue (EB)in tails

and the absorbance of the skins supernatant fluid at 590 nm was determined to react the permeability of skin capillaries indirectly.The pedal swelling model induced by carrageenan were established

and the swelling degree of the paw in various groups was observed using method of volume measurement. Inflammation model in vitro was established using RAW264.7 cells secrete inflammatory factors induced by lipopolysaccharide(LPS)

and prostaglandin E2(PGE2) content in cell supernatant of various groups was determined using enzyme-linked immunosorbant assay(ELISA) method. Result: Compared with model group

the level of EB was decreased in Bloven sustained release capsules group

NBTLH and NBTLL groups(P<0.01)

indicating that they can inhibit the increase of blood capillary permeability in rats. Compared with model group

the swelling of foot plantar in NBTLH group rats was relieved at the same time points (each time point

P<0.05).While the NBTLL group showed tendency of inhibition at various time points

but with out statistical significance.Compared with normal group

the expressions of PGE2 were elevated in the model group(P<0.05).Compared with model group

the expressions of PGE2 were significantly reduced in NBTLH and NBTLL groups(P<0.05

P<0.01). Conclusion: NBTL has an anti-inflammatory effect

which may be associated with suppressing synthesis or secretion of PGE2 in inflammatory tissues.