Objective: To observe the effect of modified Wendan Tang formulas respectively without expectorant

qi replenishing medicine

spleen tonifying medicine

qi regulating medicine and blood activation medicine

as well as modified Wendan Tang and Wendan Tang original formula on various indexes of rats with nutritional obesity. Method: Ninety SD male rats were randomly divided into 9 groups:normal group

model group

modified Wendan Tang group (8.775 g·kg-1)

Wendan Tang original formula group (5.175 g·kg-1)

A-expectorant group (6.075 g·kg-1)

A-qi replenishing medicine group (6.525 g·kg-1)

A-spleen tonifying medicine group (8.10 g·kg-1)

A-qi regulating medicine group (6.525 g·kg-1)

and A-blood activation medicine group (7.875 g·kg-1)

with 10 rats in each group. Mixed feeding of high fat emulsion

carbonated beverage plus general feed is used to copy the model of rats with nutritional obesity in all other rats except normal group

ig medication for 4 weeks. After the last drug administration for animals in each group

the rats were paunched and blood-sampled. Their serum was separated. The adipose tissue around the kidney and genital was stripped to detect the content of glucose (GLU)

total cholesterol (TC)

triglyceride(TG)

low density lipoprotein cholesterol(LDL-C)

high density lipoprotein cholesterol (HDL-C)

leptin(LEP)

adiponectin(ADP)

and insulin(INS)

and calculate the fat index. Result: Compared with the model group

modified Wendan Tang group could significantly decrease the levels of LDL-C

LEP and INS. Wendan Tang original formula group could significantly decrease the levels of TG

LEP

ADP

body weight and fat index in obese rats. A-expectorant group could reduce the level of TG. A-qitonifying medicine group could decrease the levels of TG

LEP

body weight and fat index and increase the levels of TC

LDL-C and HDL-C. A-spleen-tonifying medicine group could decrease the levels of GLU

TG and body weight. A-qiregulating medicine group could decrease the levels of TG

LEP

INS

body weight and fat index and increase the levels of LDL-C and HDL-C respectively. All these medication groups could significantly raise the rats' food intake. All the above results were statistically significant (P<0.05

P<0.01). Conclusion: All the medication groups could intervene the nutritional obesity of rats from the aspects of body weight

fat index

blood sugar

blood lipids

LEP

ADP

and INS

etc. Their roles were found to have nothing to do with the reduced feeding of rats. When observing the other indexes except TC and LDL-C

and we found that the medicine groups of Qi tonifying or Qi regulating can often be removed

while in the observation of other indexes except TG

the expectorant group should not be removed in all groups. In clinical practice

corresponding addition and subtraction of medicine compatibility should be done according to different examining indexes.