Effect of Huazhuo Tongmai Decoction in Patients with Hypertension Combined with Carotid Plaque

QIN Hai-feng; XU Jin; GUO Jiao

doi:10.13422/j.cnki.syfjx.2015210156

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Effect of Huazhuo Tongmai Decoction in Patients with Hypertension Combined with Carotid Plaque

更新时间：2024-01-04

- Effect of Huazhuo Tongmai Decoction in Patients with Hypertension Combined with Carotid Plaque
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 21, Pages: 156-159(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015210156
  CLC： R259
- Published：2015
- 稿件说明：
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QIN Hai-feng, XU Jin, GUO Jiao. Effect of Huazhuo Tongmai Decoction in Patients with Hypertension Combined with Carotid Plaque[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 156-159.
DOI：

QIN Hai-feng, XU Jin, GUO Jiao. Effect of Huazhuo Tongmai Decoction in Patients with Hypertension Combined with Carotid Plaque[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(21): 156-159. DOI： 10.13422/j.cnki.syfjx.2015210156.

摘要

目的: 观察化浊通脉汤对高血压合并颈动脉斑块患者的疗效及对炎症反应和血管内皮功能的影响。方法: 将符合条件的120例患者采用随机按数字表法分为对照组和观察组各60例。两组均严格控制血压水平

对照组给予阿托伐他汀钙片

20 mg/次

1次/d

晚上服用。观察组在对照组治疗的基础上采用化浊通脉汤内服

1剂/d。两组疗程均为4个月。采用彩色多普勒超声诊断仪检测颈动脉内膜中层厚度(IMT)

斑块数量和斑块面积;检测治疗前后甘油三酯(TG)

总胆固醇(TC)

高密度脂蛋白胆固醇(HDL-C)

低密度脂蛋白胆固醇(LDL-C)水平;检测治疗前后肿瘤坏死因子-α(TNF-α)

高敏C-反应蛋白(hs-CRP)

脂联素(APN)

一氧化氮(NO)

内皮素-1(ET-1)

并监测患者血压。结果: 治疗后两组IMT变薄

斑块个数减少

斑块面积缩小(P<0.01)

观察组上述指标的改善较对照组更为显著(P<0.05

P<0.01);治疗后两组TG

LDL-C和HDL-C异常例数均比治疗前减少(P<0.01)

观察组TG和HDL-C异常例数少于对照组(P<0.05);治疗后两组患者收缩压(SBP)和舒张压(DBP)均有所下降(P<0.05)

组间差异无统计学意义;治疗后观察组TNF-α

hs-CRP

ET-1水平低于对照组

APN和NO水平高于对照组(P<0.05

P<0.01)。结论: 化浊通脉汤联合阿托伐他汀钙片用于高血压合并颈动脉斑块患者

能减轻炎症反应

改善血管内皮功能

调节脂代谢

减少斑块个数

缩小斑块面积

这将有助于减少心脑血管疾病的发生。

Abstract

Objective: To observe the effect of Huazhuo Tongmai decoction in patients with hypertension combined with carotid plaque and its influence to inflammatory response and vascular endothelial function. Method: The 120 eligible patients were randomly divided into control group and observation group according to method of random digits table

60 cases for each group. Levels of blood pressure were controlled strictly in both groups. Patients in control group received atorvastatin calcium tablets at night

20 mg/time

1 time/day. Based on the treatment of control group

patients in observation group received additional Huazhuo Tongmai decoction

1dose/day. Course of treatment lasted for 4 months in both groups. Intima-media thickness (IMT)

quantity and area of plaque were detected by color Doppler ultrasonic diagnostic apparatus. Before and after treatment

triglyceride (TG)

total cholesterol (TC)

high-density lipoprotein-C (HDL-C)

low-density lipoprotein-C (LDL-C)

tumor necrosis factor-α (TNF-α)

high sensitivity C-reactive protein (hs-CRP)

adiponectin (APN)

nitric oxide (NO)

endothelin-1 (ET-1) and patients' blood pressure were detected. Result: IMT became thinner in both groups after treatment

and the number and area of plaques became less and small than the data before treatment (P<0.01). Those data in observation group changed more obviously than those in control group (P<0.05

P<0.01). After treatment

the number of cases with abnormal data on TG

LDL-C and HDL-C were decreased than before in both groups (P<0.01)

and the number of cases with abnormal data on TG and HDL-C in observation group was less than that in control group (P<0.05). Levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP) after treatment were decreased in both groups (P<0.05)

but there was no statistical significant difference between two groups. Levels of TNF-α

hs-CRP and ET-1 after treatment in observation group were lower than those in control group

and levels of APN and NO were higher than those in control group (P<0.05

P<0.01). Conclusion: Huazhuo Tongmai decoction combined with atorvastatin calcium tablets can relieve inflammatory reaction

ameliorate vascular endothelial function

regulate lipid metabolism

reduce quantity and area of plaques in patients with hypertension combined with carotid plaque

and it can help to reduce the risk of cardiovascular and cerebrovascular diseases.

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Related Institution

Jinan Vocational College of Nursing

Guang'anmen Hospital Jinan Hospital （Jinan Municipal Hospital of Traditional Chinese Medicine）

School of Pharmaceutical Sciences， Zhejiang Chinese Medical University

Hubei Engineering Research Center for Traditional Chinese Medicine Processing

Hubei Key Laboratory of Resource and Chemistry of Chinese Medicine，School of Pharmacy， Hubei University of Chinese Medicine

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